Description

tert-butyl N-(4-hydroxy-3-methylphenyl)carbamate (CAS No. 218966-28-0) is a high-purity carbamate derivative widely used in pharmaceutical and organic synthesis research. With the molecular formula C₁₂H₁₇NO₃, this compound serves as a versatile building block for the development of bioactive molecules. Its IUPAC name, tert-butyl N-(4-hydroxy-3-methylphenyl)carbamate, reflects its structural features, including a tert-butoxycarbonyl (Boc) protecting group and a phenolic hydroxyl moiety, making it ideal for selective deprotection and further functionalization. This product is rigorously tested for quality, ensuring optimal performance in sensitive applications. Available in various quantities, it is packaged under inert conditions to guarantee stability and longevity.

Properties

• CAS Number: 218966-28-0
• Complexity: 247
• IUPAC Name: tert-butyl N-(4-hydroxy-3-methyl-phenyl)carbamate
• InChI: InChI=1S/C12H17NO3/c1-8-7-9(5-6-10(8)14)13-11(15)16-12(2,3)4/h5-7,14H,1-4H3,(H,13,15)
• InChI Key: UFESVLDYFSGBGZ-UHFFFAOYSA-N
• Exact Mass: 223.12084340
• Molecular Formula: C12H17NO3
• Molecular Weight: 223.27
• SMILES: CC1=C(C=CC(=C1)NC(=O)OC(C)(C)C)O
• Topological: 58.6
• Monoisotopic Mass: 223.12084340
• Synonyms: 218966-28-0, tert-butyl N-(4-hydroxy-3-methylphenyl)carbamate, 958-739-8, 4-(Boc-amino)-2-methylphenol, MFCD24126282, tert-butyl (4-hydroxy-3-methylphenyl)carbamate, tert-butyl(4-hydroxy-3-methylphenyl)carbamate, SCHEMBL4700051, UFESVLDYFSGBGZ-UHFFFAOYSA-N, TIA96628, AC7978, AKOS020146086, DA-08094, SY129969, CS-0371746, EN300-113420, 1,1-dimethylethyl N-(4-hydroxy-3-methylphenyl)carbamate

Application

tert-butyl N-(4-hydroxy-3-methylphenyl)carbamate is primarily employed as an intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors and other therapeutic agents. Its Boc-protected amine group allows for selective deprotection under mild acidic conditions, facilitating stepwise organic synthesis. Researchers also utilize this compound in peptide coupling reactions and as a precursor for advanced material science applications. Its stability and reactivity make it a valuable tool for medicinal chemistry and drug discovery workflows.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.