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Atomfair 2-(2-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane C13H16BNO2 CAS 214360-48-2

2-(2-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS No. 214360-48-2) is a high-purity boronic ester derivative with the molecular formula C13H16BNO2. This compound, also known as 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, is a valuable building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. The presence of the cyano group and the pinacol boronate ester moiety makes it a versatile reagent for the introduction of aryl boronate functionalities into complex molecular architectures. This product is rigorously tested for purity and stability, ensuring optimal performance in research and industrial applications. Suitable for use in pharmaceuticals, agrochemicals, and material science, it is available in various packaging options to meet your specific needs.

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Description

2-(2-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS No. 214360-48-2) is a high-purity boronic ester derivative with the molecular formula C13H16BNO2. This compound, also known as 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, is a valuable building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. The presence of the cyano group and the pinacol boronate ester moiety makes it a versatile reagent for the introduction of aryl boronate functionalities into complex molecular architectures. This product is rigorously tested for purity and stability, ensuring optimal performance in research and industrial applications. Suitable for use in pharmaceuticals, agrochemicals, and material science, it is available in various packaging options to meet your specific needs.

Properties

  • CAS Number: 214360-48-2
  • Complexity: 329
  • IUPAC Name: 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
  • InChI: InChI=1S/C13H16BNO2/c1-12(2)13(3,4)17-14(16-12)11-8-6-5-7-10(11)9-15/h5-8H,1-4H3
  • InChI Key: SKQNWSBNAIOCOC-UHFFFAOYSA-N
  • Exact Mass: 229.1274089
  • Molecular Formula: C13H16BNO2
  • Molecular Weight: 229.08
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC=CC=C2C#N
  • Topological: 42.3
  • Monoisotopic Mass: 229.1274089
  • Synonyms: 2-(2-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 678-824-0, 214360-48-2, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, 2-Cyanophenylboronic acid pinacol ester, 2-Cyanophenylboronic acid, pinacol ester, 2-CYANOBENZENEBORONIC ACID PINACOL ESTER, MFCD04038747, 2-Cyanobenzeneboronic acid, pinacol ester, 2-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, Pinacolborane Impurity 1, Benzonitrile, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, (2-CYANOPHENYL)BORONIC ACID PINACOL ESTER, SCHEMBL520252, DTXSID40393746, BCP10609, BBL103621, STL557431, AKOS004115186, AB17166, AS-2723, CS-W000901, 2-Cyanophenylboronic acid pinacol ester, SY023526, C2621, 2-Cyanophenylboronic acid pinacol ester, 97%, EN300-1706435, 2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzonitrile, 2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile, 2-(4,4,5,5-tetramethyl[1,3,2]-dioxaborolan-2-yl)benzonitrile

Application

2-(2-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is widely used as a key intermediate in Suzuki-Miyaura cross-coupling reactions for the synthesis of biaryl compounds. Its stability and reactivity make it ideal for constructing complex organic molecules in pharmaceutical research. Additionally, it serves as a precursor in the development of advanced materials and functionalized polymers.

Safety and Hazards

GHS Hazard Statements

  • H301+H311+H331 (12.5%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
  • H302 (87.5%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (12.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (87.5%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (87.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (12.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (87.5%)
  • Acute Tox. 4 (12.5%)
  • Skin Irrit. 2 (87.5%)
  • Eye Irrit. 2 (87.5%)
  • Acute Tox. 4 (12.5%)
  • STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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