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Atomfair 2,5-Dichloro-3-nitropyridine C5H2Cl2N2O2 CAS 21427-62-3

2,5-Dichloro-3-nitropyridine (CAS No. 21427-62-3) is a high-purity nitro-substituted pyridine derivative widely utilized in pharmaceutical and agrochemical research. With the molecular formula C5H2Cl2N2O2, this compound serves as a versatile building block in organic synthesis, particularly in the development of heterocyclic compounds and active pharmaceutical ingredients (APIs). Its dichloro and nitro functional groups enable selective reactivity for nucleophilic aromatic substitution (SNAr) and reduction reactions. Offered at ≥97% purity , it is ideal for precision applications in medicinal chemistry, material science, and cross-coupling reactions. Packaged under inert conditions to ensure stability and longevity.

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Description

2,5-Dichloro-3-nitropyridine (CAS No. 21427-62-3) is a high-purity nitro-substituted pyridine derivative widely utilized in pharmaceutical and agrochemical research. With the molecular formula C5H2Cl2N2O2, this compound serves as a versatile building block in organic synthesis, particularly in the development of heterocyclic compounds and active pharmaceutical ingredients (APIs). Its dichloro and nitro functional groups enable selective reactivity for nucleophilic aromatic substitution (SNAr) and reduction reactions. Offered at ≥97% purity, it is ideal for precision applications in medicinal chemistry, material science, and cross-coupling reactions. Packaged under inert conditions to ensure stability and longevity.

Properties

  • CAS Number: 21427-62-3
  • Complexity: 161
  • IUPAC Name: 2,5-dichloro-3-nitro-pyridine
  • InChI: InChI=1S/C5H2Cl2N2O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H
  • InChI Key: OBUGJYJQJWMOQO-UHFFFAOYSA-N
  • Exact Mass: 191.9493327
  • Molecular Formula: C5H2Cl2N2O2
  • Molecular Weight: 192.98
  • SMILES: C1=C(C=NC(=C1[N+](=O)[O-])Cl)Cl
  • Topological: 58.7
  • Monoisotopic Mass: 191.9493327
  • Synonyms: 2,5-Dichloro-3-nitropyridine, 21427-62-3, DTXSID70429047, DTXCID20379881, 606-762-6, 2,5-dichloro-3-nitro-pyridine, MFCD06658963, PYRIDINE, 2,5-DICHLORO-3-NITRO-, 2.5-Dichloro-3-nitropyridine, SCHEMBL113455, 3-Nitro-2,5-dichloropyridine, OBUGJYJQJWMOQO-UHFFFAOYSA-N, BCP22209, CS-D1500, BBL100292, SBB063554, STL553862, 2,5-Dichloro-3-nitropyridine, 97%, AKOS002112621, DS-0254, PB15850, PS-4124, AC-24919, SY015627, DB-023821, A4619, D4267, EN300-102628

2,5-Dichloro-3-nitropyridine is employed as a key intermediate in synthesizing bioactive molecules, including antiviral and antibacterial agents. Its nitro group facilitates reduction to amines for further functionalization, while the chlorine atoms allow for palladium-catalyzed cross-coupling. Researchers use it in scaffold diversification for drug discovery. Suitable for Suzuki-Miyaura and Buchwald-Hartwig reactions.

Safety and Hazards

GHS Hazard Statements

  • H301 (90.9%): Toxic if swallowed [Danger Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H318 (90.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
  • H335 (97.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 3 (90.9%)
  • Skin Irrit. 2 (100%)
  • Eye Dam. 1 (90.9%)
  • STOT SE 3 (97.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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