Description

2′,3′-O-(1-Methylethylidene)inosine (CAS No. 2140-11-6) is a high-purity nucleoside derivative with the molecular formula C₁₃H₁₆N₄O₅. This chemically modified inosine analog features a protective isopropylidene group at the 2′ and 3′ positions, enhancing its stability for research applications. Ideal for oligonucleotide synthesis, biochemical studies, and pharmaceutical development, this compound is rigorously tested for quality (≥95% purity by HPLC) and supplied in lyophilized form under inert packaging. Its unique structure makes it valuable for probing RNA metabolism, antiviral research, and nucleoside transporter studies. Store at -20°C under anhydrous conditions for long-term stability.

Properties

• CAS Number: 2140-11-6
• Complexity: 513
• IUPAC Name: 9-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-1H-purin-6-one
• InChI: InChI=1S/C13H16N4O5/c1-13(2)21-8-6(3-18)20-12(9(8)22-13)17-5-16-7-10(17)14-4-15-11(7)19/h4-6,8-9,12,18H,3H2,1-2H3,(H,14,15,19)/t6-,8-,9-,12-/m1/s1
• InChI Key: LIEKLUBCIPVWQD-WOUKDFQISA-N
• Exact Mass: 308.11206962
• Molecular Formula: C13H16N4O5
• Molecular Weight: 308.29
• SMILES: CC1(O[C@@H]2[C@H](O[C@H]([C@@H]2O1)N3C=NC4=C3N=CNC4=O)CO)C
• Topological: 107
• Monoisotopic Mass: 308.11206962
• Synonyms: 2140-11-6, 2′,3′-o-(1-methylethylidene)inosine, 2′,3′-O-Isopropylideneinosine, 2′,3′-Isopropylideneinosine, 9-((3aR,4R,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ol, MFCD00038002, NSC-29925, 2′,3′-O-(1-Methylethylidene)inosine; 2′,3′-Isopropylideneinosine; NSC 29925;, Inosine, 2′,3′-O-(1-methylethylidene)-, VY7TJV832K, MLS002279957, SCHEMBL2291671, CHEMBL1591551, SCHEMBL22883487, HMS2215O16, EINECS 218-388-7, AC7786, NSC 29925, AKOS015896929, AKOS030489196, CS-W008136, DS-18563, SMR001318094, 9-((3aR,4R,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ol…

This compound serves as a key intermediate in nucleoside chemistry for RNA/DNA modification studies. Researchers utilize it to investigate enzymatic processes involving inosine kinases and phosphorylases. It is also employed in antiviral drug discovery pipelines targeting viral polymerases. The isopropylidene protection enables selective functionalization of the ribose moiety in synthetic workflows.

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