Description

3-Chloro-2-fluoroaniline (CAS No. 2106-04-9) is a high-purity aromatic amine derivative widely used in pharmaceutical, agrochemical, and specialty chemical synthesis. With the molecular formula C₆H₅ClFN, this compound serves as a versatile intermediate for constructing complex heterocyclic structures, active pharmaceutical ingredients (APIs), and fine chemicals. Our product is rigorously tested to ensure ≥97% purity (GC) and is supplied as a clear to pale yellow liquid with excellent batch-to-batch consistency. Ideal for nucleophilic substitution reactions, cross-coupling methodologies, and as a building block for fluorinated compounds, it is packaged under inert gas to maintain stability. Available in research (5g-100g), pilot (250g-1kg), and bulk (5kg+) quantities with optional custom purity specifications.

Properties

• CAS Number: 2106-04-9
• Complexity: 99.1
• IUPAC Name: 3-chloro-2-fluoro-aniline
• InChI: InChI=1S/C6H5ClFN/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2
• InChI Key: XWBTZHDDWRNOQH-UHFFFAOYSA-N
• Exact Mass: 145.0094550
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.56
• SMILES: C1=CC(=C(C(=C1)Cl)F)N
• Topological: 26
• Monoisotopic Mass: 145.0094550
• Synonyms: 3-Chloro-2-fluoroaniline, 2106-04-9, Benzenamine, 3-chloro-2-fluoro-, 3-Chloro-2-fluorobenzenamine, Aniline, 3-chloro-2-fluoro-, DTXSID0062183, EINECS 218-283-6, DTXCID5036420, 218-283-6, 2-fluoro-3-chloroaniline, MFCD00069415, 3-chloro-2-fluorophenylamine, 3,4-chlorofluoroaniline, 3-chloro-2 fluoroaniline, 2-fluoro-3-chloro-aniline, 3-chloro-2-fluoro aniline, 3-chloro-2-fluoro-aniline, B8HNF595PA, SCHEMBL112253, 3-Chloro-2-fluoro-phenylamine, SCHEMBL1383972, (3-Chloro-2-fluorophenyl)amine, SCHEMBL28720950, 3-Chloro-2-fluoroaniline, 97%, HMS1788P03, SBB004108, STL168045, AKOS001116290, CS-W019569, FC64318, PS-8956, AC-13781, DB-028421, C1659, NS00093507, ST50823994, EN300-18758, D71211

3-Chloro-2-fluoroaniline is primarily employed as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly for CNS-active compounds and antibacterial agents. It serves as a precursor for Suzuki-Miyaura cross-coupling reactions to create biaryl structures in drug discovery. The compound also finds use in agricultural chemistry for developing novel pesticides and herbicides with enhanced activity. Researchers utilize its reactive amine group for diazotization and subsequent functionalization in dye chemistry.

Safety and Hazards

GHS Hazard Statements

• H302 (96.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (92.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (80.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (11.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (15.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (82.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (96.2%)
• Skin Irrit. 2 (92.3%)
• Eye Dam. 1 (80.8%)
• Eye Irrit. 2 (11.5%)
• Acute Tox. 4 (15.4%)
• STOT SE 3 (82.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.