Description

3,5-Difluorobenzenesulfonyl chloride (CAS No. 210532-25-5) is a high-purity sulfonyl chloride derivative with the molecular formula C₆H₃ClF₂O₂S. This compound is a versatile reagent widely used in organic synthesis, particularly in the preparation of sulfonamides and sulfonate esters. Its unique 3,5-difluoro substitution pattern enhances reactivity and selectivity in electrophilic aromatic substitution reactions. Ideal for pharmaceutical and agrochemical research, this compound is supplied as a crystalline solid with >98% purity (HPLC), ensuring consistent performance in demanding synthetic applications. Proper handling under inert conditions is recommended due to its moisture sensitivity.

Properties

• CAS Number: 210532-25-5
• Complexity: 239
• IUPAC Name: 3,5-difluorobenzenesulfonyl chloride
• InChI: InChI=1S/C6H3ClF2O2S/c7-12(10,11)6-2-4(8)1-5(9)3-6/h1-3H
• InChI Key: IIQKIICAOXAXEJ-UHFFFAOYSA-N
• Exact Mass: 211.9510345
• Molecular Formula: C6H3ClF2O2S
• Molecular Weight: 212.60
• SMILES: C1=C(C=C(C=C1F)S(=O)(=O)Cl)F
• Topological: 42.5
• Monoisotopic Mass: 211.9510345
• Synonyms: 3,5-Difluorobenzenesulfonyl chloride, 210532-25-5, DTXSID30378865, DTXCID30329892, 625-780-5, 3,5-difluorobenzene-1-sulfonyl chloride, 3,5-Difluorobenzenesulphonyl chloride, BENZENESULFONYL CHLORIDE, 3,5-DIFLUORO-, 3,5-Difluorobenzenesulphonylchloride, 3,5-Difluorobenzenesulfonylchloride, MFCD02091378, SCHEMBL67496, 3,5-difluorophenyl sulfonylchloride, 3,5-difluorophenyl-sulfonylchloride, ALBB-001015, BBL017941, SBB018121, STK502406, 3,5-difluoro-benzenesulfonyl chloride, 3,5-difluorobenzene sulfonyl chloride, AKOS000200710, AKOS024327982, 3,5-difluorobenzene-1-sulfonylchloride, AB10702, CS-W007629, PS-10906, 3,5-Difluorobenzenesulfonyl chloride, 97%, A4563, EN300-21872, F2145-0712, Z147640958

Application

3,5-Difluorobenzenesulfonyl chloride is primarily employed as a key intermediate in the synthesis of biologically active sulfonamide compounds. It is widely used in pharmaceutical research for developing enzyme inhibitors and receptor modulators. Additionally, this reagent finds applications in material science for modifying polymer surfaces and creating specialized coatings. Its reactivity with amines and alcohols makes it valuable for constructing complex molecular architectures in medicinal chemistry.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)

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