Description

4′-Fluoro-3′-(trifluoromethyl)acetophenone (CAS No. 208173-24-4) is a high-purity fluorinated aromatic ketone with the molecular formula C₉H₆F₄O. This compound, also known by its IUPAC name 1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone, is a valuable building block in organic synthesis and pharmaceutical research. Its unique structure, featuring both fluorine and trifluoromethyl substituents, enhances its reactivity and utility in cross-coupling reactions, nucleophilic substitutions, and as a precursor for advanced intermediates. Suitable for use in medicinal chemistry, material science, and agrochemical development, this product is rigorously tested for purity and consistency. Packaged under inert conditions to ensure stability, it is ideal for researchers requiring reliable and high-quality fluorinated compounds.

Properties

• CAS Number: 208173-24-4
• Complexity: 223
• IUPAC Name: 1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone
• InChI: InChI=1S/C9H6F4O/c1-5(14)6-2-3-8(10)7(4-6)9(11,12)13/h2-4H,1H3
• InChI Key: SYFHRXQPXHETEF-UHFFFAOYSA-N
• Exact Mass: 206.03547746
• Molecular Formula: C9H6F4O
• Molecular Weight: 206.14
• SMILES: CC(=O)C1=CC(=C(C=C1)F)C(F)(F)F
• Topological: 17.1
• Monoisotopic Mass: 206.03547746
• Synonyms: 4′-Fluoro-3′-(trifluoromethyl)acetophenone, 642-880-4, 208173-24-4, 1-(4-Fluoro-3-(trifluoromethyl)phenyl)ethanone, 1-[4-Fluoro-3-(trifluoromethyl)phenyl]ethanone, 4-Fluoro-3-(trifluoromethyl)acetophenone, Ethanone, 1-[4-fluoro-3-(trifluoromethyl)phenyl]-, 1-[4-fluoro-3-(trifluoromethyl)phenyl]ethan-1-one, MFCD00061252, 4′-fluoro-3′-trifluoromethylacetophenone, 1-acetyl-4-fluoro-3-(trifluoromethyl)benzene, 5-Acetyl-2-fluorobenzotrifluoride, SCHEMBL78909, SCHEMBL3633190, DTXSID60345580, CL8670, SBB064364, AKOS005259007, AC-3621, PS-8079, 4-fluoro-3-(trifluormethyl)acetophenone, SY017078, CS-0020108, F0808, ST50406997, 1-(4-fluoro-3-trifluoromethyl-phenyl)-ethanone, 1-[4-fluoranyl-3-(trifluoromethyl)phenyl]ethanone, 1-[4-Fluoro-3-(trifluoromethyl)phenyl]ethanone #, A814941, 4 inverted exclamation mark -Fluoro-3 inverted exclamation mark -(trifluoromethyl)acetophenone

Application

4′-Fluoro-3′-(trifluoromethyl)acetophenone is widely used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of bioactive molecules with enhanced metabolic stability and lipophilicity. Its fluorinated aromatic core makes it valuable for designing kinase inhibitors, anti-inflammatory agents, and CNS-targeting compounds. Additionally, it serves as a versatile precursor in material science for creating specialty polymers and liquid crystals with unique electronic properties. Researchers also leverage its reactivity in agrochemical applications to develop novel pesticides and herbicides.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (75%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.