Description

4-Fluoro-2-(trifluoromethyl)benzyl bromide (CAS No. 206860-48-2) is a high-purity, fluorinated organic compound with the molecular formula C₈H₅BrF₄. This versatile reagent is widely used in pharmaceutical, agrochemical, and materials science research due to its reactive benzyl bromide moiety and trifluoromethyl group, which enhance its utility in nucleophilic substitution reactions, cross-coupling, and as a building block for complex fluorinated molecules. Available at 98% purity, it is supplied in rigorously tested batches to ensure consistency for synthetic applications. Suitable for use in inert atmospheres and moisture-sensitive reactions, this compound is a critical intermediate for developing bioactive compounds, liquid crystals, and advanced polymers. Store in a cool, dry place under nitrogen to maintain stability.

Properties

• CAS Number: 206860-48-2
• Complexity: 168
• IUPAC Name: 1-(bromomethyl)-4-fluoro-2-(trifluoromethyl)benzene
• InChI: InChI=1S/C8H5BrF4/c9-4-5-1-2-6(10)3-7(5)8(11,12)13/h1-3H,4H2
• InChI Key: JMNOONULDANZRZ-UHFFFAOYSA-N
• Exact Mass: 255.95108
• Molecular Formula: C8H5BrF4
• Molecular Weight: 257.02
• SMILES: C1=CC(=C(C=C1F)C(F)(F)F)CBr
• Monoisotopic Mass: 255.95108
• Synonyms: 206860-48-2, 4-Fluoro-2-(trifluoromethyl)benzyl bromide, DTXSID80372156, DTXCID40323189, 625-261-3, 1-(Bromomethyl)-4-fluoro-2-(trifluoromethyl)benzene, 4-fluoro-2-(trifluoromethyl)benzylbromide, BENZENE, 1-(BROMOMETHYL)-4-FLUORO-2-(TRIFLUOROMETHYL)-, MFCD00061176, SCHEMBL488748, SBB101811, AKOS015853469, FF87165, JS-4092, 4-fluoro-2-trifluoromethylbenzyl bromide, 4-fluoro-2-trifluoromethyl-benzyl bromide, AC-26198, F1149, ST51028408, 1-bromomethyl-4-fluoro-2-trifluoromethyl-benzene, EN300-1934621, 4-Fluoro-2-(trifluoromethyl)benzyl bromide, 98%

4-Fluoro-2-(trifluoromethyl)benzyl bromide is a key intermediate in synthesizing fluorinated aromatic compounds for drug discovery and agrochemicals. It is employed in Suzuki-Miyaura cross-coupling reactions to introduce fluorinated benzyl groups into target molecules. Researchers also utilize it to develop liquid crystal materials and specialty polymers with enhanced thermal and chemical resistance. Its reactivity makes it valuable for constructing trifluoromethyl-substituted scaffolds in medicinal chemistry.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)

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