Description

(2-Fluoropyridin-3-yl)methanamine (CAS No. 205744-16-7) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₇FN₂. This specialized amine compound features a reactive primary amine group attached to a 2-fluoropyridine scaffold, making it a valuable building block for pharmaceutical and agrochemical synthesis. The fluorine substitution at the 2-position of the pyridine ring enhances its potential as a directing group in metal-catalyzed cross-coupling reactions. Our product is rigorously quality-controlled to ensure >95% purity (HPLC) and is supplied as a clear to pale yellow liquid under inert atmosphere packaging. Ideal for medicinal chemistry applications, this compound is particularly useful in the development of kinase inhibitors and other biologically active molecules where the 2-fluoropyridine moiety can serve as a privileged structure.

Key Specifications:
– CAS: 205744-16-7
– Molecular Weight: 126.13 g/mol
– Purity: ≥95% (HPLC)
– Storage: 2-8°C under inert gas
– Hazard Codes: Corrosive

Properties

• CAS Number: 205744-16-7
• Complexity: 87.1
• IUPAC Name: (2-fluoro-3-pyridyl)methanamine
• InChI: InChI=1S/C6H7FN2/c7-6-5(4-8)2-1-3-9-6/h1-3H,4,8H2
• InChI Key: ORBSSWJRHPFEBR-UHFFFAOYSA-N
• Exact Mass: 126.05932639
• Molecular Formula: C6H7FN2
• Molecular Weight: 126.13
• SMILES: C1=CC(=C(N=C1)F)CN
• Topological: 38.9
• Monoisotopic Mass: 126.05932639
• Synonyms: (2-Fluoropyridin-3-yl)methanamine, 205744-16-7, 2-Fluoro-3-pyridinemethanamine, (2-Fluoro-3-pyridyl)methanamine, 3-PYRIDINEMETHANAMINE, 2-FLUORO-, 3-Aminomethyl-2-fluoropyridine, MFCD06213866, 1-(2-Fluoropyridin-3-yl)methanamine, SCHEMBL1146338, 2-fluoro-pyridin-3-ylmethylamine, DTXSID00663775, ORBSSWJRHPFEBR-UHFFFAOYSA-N, BDBM557619, US11358936, Compound 4-1, AKOS006292551, C-(2-fluoro-pyridin-3-yl)methylamine, AB23466, SB75675, DS-11767, DB-066245, CS-0112238, EN300-193280

Application

(2-Fluoropyridin-3-yl)methanamine serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors and CNS-active drugs. The fluoropyridine scaffold demonstrates improved metabolic stability and membrane permeability in drug candidates. This building block is frequently employed in palladium-catalyzed cross-coupling reactions and reductive amination procedures. Researchers utilize it to introduce both the fluoropyridine moiety and a reactive amine handle into target molecules.

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