Description

5-Fluoro-2-methoxyaniline (CAS No. 1978-39-8) is a high-purity aromatic amine derivative with the molecular formula C₇H₈FNO. This compound, also known by its IUPAC name 5-fluoro-2-methoxyaniline, is a valuable building block in organic synthesis and pharmaceutical research. It features a fluorine substituent at the 5-position and a methoxy group at the 2-position of the aniline ring, offering unique electronic and steric properties for regioselective reactions. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied as a light yellow to brown crystalline solid with excellent shelf stability under recommended storage conditions (2-8°C, inert atmosphere). Ideal for use in Suzuki couplings, Buchwald-Hartwig aminations, and other palladium-catalyzed transformations. Available in research quantities (100mg to 100g) with optional custom packaging and purity requirements.

Properties

• CAS Number: 1978-39-8
• Complexity: 110
• IUPAC Name: 5-fluoro-2-methoxy-aniline
• InChI: InChI=1S/C7H8FNO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,9H2,1H3
• InChI Key: VYZUBHRSGQAROM-UHFFFAOYSA-N
• Exact Mass: 141.058992041
• Molecular Formula: C7H8FNO
• Molecular Weight: 141.14
• SMILES: COC1=C(C=C(C=C1)F)N
• Topological: 35.3
• Monoisotopic Mass: 141.058992041
• Synonyms: 5-Fluoro-2-methoxyaniline, 2-fluoro-N-methylbenzenamine, DTXSID50278853, DTXCID20230009, 625-506-4, 1978-39-8, 2-Amino-4-fluoroanisole, 5-Fluoro-2-methoxyphenylamine, Benzenamine, 5-fluoro-2-methoxy-, 5-Fluoro-o-anisidine, 3-FLUORO-6-METHOXYANILINE, 2-Amino-4-fluoro-1-methoxybenzene, MFCD00077537, 5-Fluoro-2-methoxybenzenamine, 5-fluoro-2-methoxy-aniline, NSC10341, 4-fluoro-2-aminoanisole, 2-methoxy-5-fluoroaniline, 2-methoxyl-5-fluoroaniline, SCHEMBL112310, 5-fluoro-2-methoxy-phenylamine, SCHEMBL16974741, 5-Fluoro-2-methoxyaniline, 97%, BCP05920, NSC-10341, SBB051693, AKOS000222300, AC-3685, CS-W008250, PS-9019, SY009788, DB-024339, A4335, F0614, ST50949459, EN300-80003, Z332375930

Application

5-Fluoro-2-methoxyaniline serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors and antipsychotic agents. The compound’s electron-rich aniline core makes it valuable for constructing heterocyclic scaffolds in medicinal chemistry. Researchers utilize it as a precursor for fluorescent probes due to the conjugation-enhancing effects of the fluorine and methoxy substituents. In material science, it finds application in the preparation of advanced polyimides and liquid crystal materials.

Safety and Hazards

GHS Hazard Statements

• H301 (15.2%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (84.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (15.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (84.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (13%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (15.2%)
• Acute Tox. 4 (84.8%)
• Acute Tox. 3 (15.2%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (84.8%)
• STOT RE 2 (13%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.