Description

rac-tert-butyl (3R,5R)-3-amino-5-fluoropiperidine-1-carboxylate (CAS: 1932056-72-8) is a high-purity chiral piperidine derivative designed for advanced pharmaceutical and chemical research applications. This compound features a tert-butoxycarbonyl (Boc) protecting group and a fluorine substitution at the 5-position, making it a versatile intermediate in medicinal chemistry and drug discovery. With the molecular formula C₁₀H₁₉FN₂O₂, it offers excellent stability and reactivity for stereoselective synthesis. Ideal for researchers developing bioactive molecules, this product is rigorously tested for purity (≥95% by HPLC) and is supplied in sealed containers under inert gas to ensure long-term integrity. Store at 2-8°C in a dry environment to maintain optimal performance.

Properties

• CAS Number: 1932056-72-8
• Complexity: 240
• IUPAC Name: tert-butyl (3S,5S)-3-amino-5-fluoro-piperidine-1-carboxylate
• InChI: InChI=1S/C10H19FN2O2/c1-10(2,3)15-9(14)13-5-7(11)4-8(12)6-13/h7-8H,4-6,12H2,1-3H3/t7-,8-/m0/s1
• InChI Key: QHVIBSNJHHGNCZ-YUMQZZPRSA-N
• Exact Mass: 218.14305602
• Molecular Formula: C10H19FN2O2
• Molecular Weight: 218.27
• SMILES: CC(C)(C)OC(=O)N1C[C@H](C[C@@H](C1)F)N
• Topological: 55.6
• Monoisotopic Mass: 218.14305602
• Synonyms: tert-butyl (3S,5S)-3-amino-5-fluoropiperidine-1-carboxylate, 1932056-72-8, 1638772-27-6, RAC-TERT-BUTYL (3R,5R)-3-AMINO-5-FLUOROPIPERIDINE-1-CARBOXYLATE, 816-139-2, 860-638-8, (3S,5S)-tert-Butyl 3-amino-5-fluoropiperidine-1-carboxylate, rac-tert-butyl (3R,5R)-3-amino-5-fluoropiperidine-1-carboxylate, trans, MFCD30181025, (3S,5S)-1-Boc-3-amino-5-fluoropiperidine, CHEMBL4589098, SCHEMBL20497892, AKOS030627761, DB-144713, CS-0055771, EN300-300141, P15617, EN300-6490282, Z2311227707, t-Butyl (3S,5S)-3-amino-5-fluoropiperidine-1-carboxylate, (3S,5S)-tert-Butyl3-amino-5-fluoropiperidine-1-carboxylate

This compound serves as a key chiral building block in the synthesis of fluorinated pharmaceuticals, particularly for CNS-targeting drugs and enzyme inhibitors. Its Boc-protected amino group enables selective deprotection for further functionalization, while the fluorine atom enhances metabolic stability in drug candidates. Researchers utilize it in asymmetric synthesis, peptide mimetics, and structure-activity relationship (SAR) studies. The racemic mixture allows investigation of both enantiomers’ biological activity during early-stage drug development.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.