Description

4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline (CAS No. 190728-25-7) is a high-purity quinoline derivative with the molecular formula C₁₇H₁₆N₂O₃. This compound features a quinoline core substituted with dimethoxy groups at the 6 and 7 positions, and an aniline moiety linked via an ether bridge at the 4-position. Its IUPAC name is 4-(6,7-dimethoxyquinolin-4-yl)oxyaniline. This chemical is ideal for pharmaceutical research, organic synthesis, and as a building block for drug discovery. It is supplied as a solid with ≥95% purity (HPLC), ensuring consistency for sensitive applications. Store in a cool, dry place, protected from light and moisture to maintain stability.

Properties

• CAS Number: 190728-25-7
• Complexity: 347
• IUPAC Name: 4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline
• InChI: InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3
• InChI Key: VXEQRXJATQUJSN-UHFFFAOYSA-N
• Exact Mass: 296.11609238
• Molecular Formula: C17H16N2O3
• Molecular Weight: 296.32
• SMILES: COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)N
• Topological: 66.6
• Monoisotopic Mass: 296.11609238
• Synonyms: 190728-25-7, 4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline, 4-[(6,7-dimethoxyquinolin-4-yl)oxy]aniline, 833-600-3, 4-(6,7-DIMETHOXY-QUINOLIN-4-YLOXY)-PHENYLAMINE, 4-(6,7-dimethoxyquinolin-4-yl)oxyaniline, Benzenamine, 4-[(6,7-dimethoxy-4-quinolinyl)oxy]-, 6,7-Dimethoxy-4-(4-aminophenoxy)quinoline, MFCD19685633, 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline, 4-(4-Aminophenoxy)-6,7-dimethoxyquinoline, 4-(6,7-dimethoxyquinolin-4-yloxy)phenylamine, BENZENAMINE, 4-((6,7-DIMETHOXY-4-QUINOLINYL)OXY)-, 4-(6,7-dimethoxyquinolin-4-yloxy)aniline, 4-[(6,7-Dimethoxy-4-quinolinyl)oxy]benzenamine; 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline; 6,7-Dimethoxy-4-(4-aminophenoxy)quinoline;[4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl]amine;, A3DFP7AR57, SCHEMBL167396, CHEMBL3667501, DTXSID40469172, VXEQRXJATQUJSN-UHFFFAOYSA-N, BDBM153646, BCP10283, AKOS005261203, CCG-332646, SB18182, 4-(6,7-Dimethoxy-4-quinolyloxy)aniline, AC-29723, AS-19585, PD121370, SY212142, 4-[(6,7Dimethoxy-4-quinolyl)oxy]aniline, DB-350275, CS-0043365, D5070, 4-(6,7-Dimethoxyquinolin-4-yloxy)benzenamine, 4-[(6,7-Dimethoxy-4-quinolyl)oxy-]aniline, 6,7-Dimethoxy-4-(4-aminophenyloxy)quinoline, EN300-373698, 4-[(6,7-Dimethoxy-4-quinolinyl)oxy]benzenamine, 4-(6,7-Dimethoxy-quinoline-4-yloxy)-phenylamine, [4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl]amine, Z2784150670, US8999982, 4-((6,7-dimethoxyquinolin-4- yl)oxy)aniline, 6,7-Dimethoxy-4-(4-aminophenoxy)quinoline;4-(6,7-dimethoxyquinolin-4-yl)oxyaniline

Application

4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline is a versatile intermediate in medicinal chemistry, particularly for the synthesis of kinase inhibitors and anticancer agents. Its quinoline scaffold makes it valuable for designing compounds targeting signal transduction pathways. Researchers also utilize it in fluorescent probes due to its aromatic structure. The aniline group allows further functionalization via diazotization or amide coupling.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)

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