Description

3,4-Difluoro-2-hydroxybenzoic acid (CAS No. 189283-51-0) is a fluorinated benzoic acid derivative with the molecular formula C₇H₄F₂O₃. This high-purity compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. The presence of both fluorine substituents and a hydroxyl group on the aromatic ring enhances its reactivity, making it a versatile intermediate for designing novel bioactive molecules. Our product is rigorously tested to ensure ≥95% purity (HPLC) and is supplied as a white to off-white crystalline powder. Suitable for use in medicinal chemistry, material science, and as a precursor for advanced fluorinated compounds. Store in a cool, dry place away from light and moisture.

Properties

• CAS Number: 189283-51-0
• Complexity: 185
• IUPAC Name: 3,4-difluoro-2-hydroxy-benzoic acid
• InChI: InChI=1S/C7H4F2O3/c8-4-2-1-3(7(11)12)6(10)5(4)9/h1-2,10H,(H,11,12)
• InChI Key: GWOOBUWKTOCYKY-UHFFFAOYSA-N
• Exact Mass: 174.01285031
• Molecular Formula: C7H4F2O3
• Molecular Weight: 174.10
• SMILES: C1=CC(=C(C(=C1C(=O)O)O)F)F
• Topological: 57.5
• Monoisotopic Mass: 174.01285031
• Synonyms: 3,4-difluoro-2-hydroxybenzoic acid, 189283-51-0, DTXSID90374262, DTXCID30325293, 630-145-0, 642-481-5, 3,4-difluorosalicylic acid, Benzoic acid, 3,4-difluoro-2-hydroxy-, MFCD03428564, 3,4-difluoro-2-hydroxy-benzoic Acid, SCHEMBL1922498, CHEMBL3793889, 3,4-difluoro-hydroxybenzoic acid, GWOOBUWKTOCYKY-UHFFFAOYSA-N, 3,4-difluoro-2-hydroxybenzoicacid, 3,4-difluro-2-hydroxybenzoic acid, SBB088848, 3,4-difluoro-2-hydroxy benzoic acid, 3,4-difluoro-2-hydroxybenzoic acid;, AKOS012335373, FD65685, AS-19927, BP-10523, SY106631, CS-0067839, EN300-159998

Application

3,4-Difluoro-2-hydroxybenzoic acid is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its unique structure allows for further functionalization, making it valuable in drug discovery for modifying pharmacokinetic properties. Researchers also utilize this compound in material science for developing specialty polymers with enhanced stability. The fluorine atoms contribute to increased lipophilicity, improving membrane permeability in bioactive molecules.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (12.5%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (12.5%)
• Eye Irrit. 2 (87.5%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.