Description

(4-Bromo-2-fluorophenyl)methanol (CAS No. 188582-62-9) is a high-purity aromatic alcohol derivative with the molecular formula C₇H₆BrFO. This compound features a bromo and fluoro substitution on the phenyl ring, making it a versatile intermediate for pharmaceutical, agrochemical, and materials science research. Its benzyl alcohol moiety enhances reactivity in nucleophilic substitutions and cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings. With a molecular weight of 205.03 g/mol, it is supplied as a white to off-white crystalline solid with ≥95% purity (HPLC). Ideal for synthetic organic chemists, this product is rigorously tested for consistency, stability, and low trace metal content. Store under inert conditions at 2-8°C to maintain integrity.

Properties

• CAS Number: 188582-62-9
• Complexity: 110
• IUPAC Name: (4-bromo-2-fluoro-phenyl)methanol
• InChI: InChI=1S/C7H6BrFO/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2
• InChI Key: BWBJZMQPVBWEJU-UHFFFAOYSA-N
• Exact Mass: 203.95861
• Molecular Formula: C7H6BrFO
• Molecular Weight: 205.02
• SMILES: C1=CC(=C(C=C1Br)F)CO
• Topological: 20.2
• Monoisotopic Mass: 203.95861
• Synonyms: (4-bromo-2-fluorophenyl)methanol, 672-500-2, 4-Bromo-2-fluorobenzyl alcohol, 188582-62-9, Benzenemethanol, 4-bromo-2-fluoro-, 4-bromo-2-fluorobenzylalcohol, MFCD00143265, (4-Bromo-2-fluoro-phenyl)methanol, (4-bromo-2-fluorophenyl)methan-1-ol, SCHEMBL507839, SCHEMBL2094594, 4-bromo-2-fluoro-benzyl alcohol, DTXSID50370088, BWBJZMQPVBWEJU-UHFFFAOYSA-N, (4-bromo-2-fluoro-phenyl)-methanol, SBB005826, AKOS005254291, 4-Bromo-2-fluorobenzyl alcohol, 97%, FB67929, PS-8127, ST065684, SY019197, DB-030587, CS-0040412, EN300-101362, F13687, F8887-2027

Application

(4-Bromo-2-fluorophenyl)methanol serves as a key building block in the synthesis of bioactive molecules, including kinase inhibitors and fluorinated drug candidates. It is employed in palladium-catalyzed cross-coupling reactions to introduce functionalized aryl groups into complex scaffolds. Researchers also utilize it to develop liquid crystals and OLED materials due to its halogenated aromatic structure.

Safety and Hazards

GHS Hazard Statements

• H302 (86.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (86.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.