Description

tert-Butyl 4-(1-hydroxyethyl)piperidine-1-carboxylate (CAS No. 183170-69-6) is a high-purity, synthetic organic compound widely used in pharmaceutical and chemical research. This Boc-protected piperidine derivative features a hydroxyl group at the 1-position of the ethyl side chain, enhancing its reactivity and utility in multi-step syntheses. With a molecular formula of C₁₂H₂₃NO₃ and a molecular weight of 229.32 g/mol, it is a versatile intermediate for drug discovery, peptide chemistry, and catalyst development. Available in ≥95% purity (HPLC/GC), this compound is supplied as a white to off-white crystalline powder, soluble in common organic solvents such as DCM, DMF, and methanol. Strictly handled under inert conditions to ensure stability, it is ideal for academic, industrial, and medicinal chemistry applications.

Properties

• CAS Number: 183170-69-6
• Complexity: 239
• IUPAC Name: tert-butyl 4-(1-hydroxyethyl)piperidine-1-carboxylate
• InChI: InChI=1S/C12H23NO3/c1-9(14)10-5-7-13(8-6-10)11(15)16-12(2,3)4/h9-10,14H,5-8H2,1-4H3
• InChI Key: SQOMPUDOUGDJPH-UHFFFAOYSA-N
• Exact Mass: 229.16779360
• Molecular Formula: C12H23NO3
• Molecular Weight: 229.32
• SMILES: CC(C1CCN(CC1)C(=O)OC(C)(C)C)O
• Topological: 49.8
• Monoisotopic Mass: 229.16779360
• Synonyms: 183170-69-6, TERT-BUTYL 4-(1-HYDROXYETHYL)PIPERIDINE-1-CARBOXYLATE, DTXSID90621268, DTXCID70572022, 1-Piperidinecarboxylic acid, 4-(1-hydroxyethyl)-, 1,1-dimethylethyl ester, 4-(1-HYDROXY-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, MFCD15474944, 1-tert-Butoxycarbonyl-4-(1-hydroxyethyl)piperidine; 4-(1-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester, MFCD22666103, MFCD22666104, 1-(1-Boc-4-piperidyl)ethanol, 1-tert-Butyloxycarbonyl-4-hydroxyethylpiperidine, SCHEMBL387237, SCHEMBL5341723, SCHEMBL27621852, SQOMPUDOUGDJPH-UHFFFAOYSA-N, IHA17069, 1-Boc-4-(1-Hydroxyethyl)piperidine, (R)-1-(1-Boc-4-piperidyl)ethanol, AKOS022931227, SB23153, AS-42642, DA-09003, SY035992, SY037706, SY344339, (S)-1-Boc-4-(1-hydroxyethyl)piperidine, CS-0011606, EN300-3572171, N-t-Butoxycarbonyl-4-(1-hydroxyethyl)piperidine, N-tert-butoxycarbonyl-4-(1-hydroxyethyl)piperidine, F1907-2539, TERT-BUTYL4-(1-HYDROXYETHYL)PIPERIDINE-1-CARBOXYLATE, (+/-)-1,1-dimethylethyl 4-(1-hydroxyethyl)-1-piperidinecarboxylate, 1-?Piperidinecarboxylic acid, 4-?(1-?hydroxyethyl)?-?, 1,?1-?dimethylethyl ester

tert-Butyl 4-(1-hydroxyethyl)piperidine-1-carboxylate serves as a key intermediate in the synthesis of bioactive molecules, including kinase inhibitors and CNS-targeting pharmaceuticals. Its Boc-protected amine and hydroxyl functionalities enable selective deprotection for modular derivatization. Commonly employed in peptidomimetics and chiral auxiliaries, it also aids in asymmetric catalysis and ligand design. Researchers leverage its structural motifs for fragment-based drug discovery and PROTAC development.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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