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Atomfair 5-Amino-2-fluoropyridine C5H5FN2 CAS 1827-27-6

5-Amino-2-fluoropyridine (CAS No. 1827-27-6) is a high-purity fluorinated pyridine derivative with the molecular formula C5H5FN2. This compound is an essential building block in pharmaceutical and agrochemical synthesis, particularly for the development of active pharmaceutical ingredients (APIs) and specialty chemicals. With a purity of 97% , it is ideal for research applications requiring precise molecular modifications. The product is supplied as a fine crystalline powder, ensuring easy handling and solubility in common organic solvents. Its unique structure, featuring both an amino and a fluorine substituent on the pyridine ring, enables versatile reactivity in nucleophilic substitution and coupling reactions. Suitable for use…

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Description

5-Amino-2-fluoropyridine (CAS No. 1827-27-6) is a high-purity fluorinated pyridine derivative with the molecular formula C5H5FN2. This compound is an essential building block in pharmaceutical and agrochemical synthesis, particularly for the development of active pharmaceutical ingredients (APIs) and specialty chemicals. With a purity of 97%, it is ideal for research applications requiring precise molecular modifications. The product is supplied as a fine crystalline powder, ensuring easy handling and solubility in common organic solvents. Its unique structure, featuring both an amino and a fluorine substituent on the pyridine ring, enables versatile reactivity in nucleophilic substitution and coupling reactions. Suitable for use in HPLC, NMR, and LC-MS analysis, this reagent meets stringent quality standards for laboratory and industrial use.

Properties

  • CAS Number: 1827-27-6
  • Complexity: 76.8
  • IUPAC Name: 6-fluoropyridin-3-amine
  • InChI: InChI=1S/C5H5FN2/c6-5-2-1-4(7)3-8-5/h1-3H,7H2
  • InChI Key: YTHMOBMZVVFNBE-UHFFFAOYSA-N
  • Exact Mass: 112.04367633
  • Molecular Formula: C5H5FN2
  • Molecular Weight: 112.10
  • SMILES: C1=CC(=NC=C1N)F
  • Topological: 38.9
  • Monoisotopic Mass: 112.04367633
  • Synonyms: 5-Amino-2-fluoropyridine, 1827-27-6, 6-fluoro-3-pyridinamine, DTXSID30356082, DTXCID40307141, 675-011-2, 6-fluoropyridin-3-amine, 2-fluoro-5-aminopyridine, 3-PYRIDINAMINE, 6-FLUORO-, 6-fluoro-pyridin-3-ylamine, MFCD01632180, 6-fluoro-3-pyridylamine, 6-fluoropyridin-3-ylamine, 6-Fluoro-3-pyridinylamine, 5-amino-2-fluoro-pyridine, SCHEMBL361163, SCHEMBL2643449, SCHEMBL29023535, 5-Amino-2-fluoropyridine, 97%, YTHMOBMZVVFNBE-UHFFFAOYSA-N, BCP23168, CS-D0790, BBL103227, SBB051873, STL557037, AKOS005064010, PB33962, PS-9248, AC-25154, HY-65254, SY014297, DB-012972, A2384, EN300-104103, AJ-333/36120022, 6-Fluoropyridin-3-amine;2-Fluoro-5-aminopyridine;3-Amino-6-fluoropyridine

5-Amino-2-fluoropyridine is widely used as a key intermediate in the synthesis of pharmaceuticals, including kinase inhibitors and antiviral agents. It serves as a precursor for fluorinated heterocycles in medicinal chemistry and material science. Researchers leverage its reactivity in palladium-catalyzed cross-coupling reactions to construct complex molecular architectures. The compound is also employed in agrochemical research for developing novel pesticides and herbicides.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H318 (82.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
  • H319 (17.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Dam. 1 (82.6%)
  • Eye Irrit. 2A (17.4%)
  • STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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