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Atomfair 3,3-Difluoro-D-proline C5H7F2NO2 CAS 1821782-74-4

3,3-Difluoro-D-proline (CAS No. 1821782-74-4) is a high-purity fluorinated proline derivative designed for advanced research and pharmaceutical applications. This compound, with the molecular formula C5H7F2NO2, features a stereospecific (S)-configuration and two fluorine atoms at the 3-position, enhancing its utility in peptide modification, medicinal chemistry, and enzyme inhibition studies. Its rigid pyrrolidine backbone and fluorine substitution make it ideal for probing conformational effects, improving metabolic stability, and optimizing bioactivity in drug design. Available in >98% purity (HPLC), this product is rigorously tested for quality and consistency, ensuring reliable performance in synthetic and biochemical applications. Suitable for use in solid-phase peptide synthesis (SPPS),…

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Description

3,3-Difluoro-D-proline (CAS No. 1821782-74-4) is a high-purity fluorinated proline derivative designed for advanced research and pharmaceutical applications. This compound, with the molecular formula C5H7F2NO2, features a stereospecific (S)-configuration and two fluorine atoms at the 3-position, enhancing its utility in peptide modification, medicinal chemistry, and enzyme inhibition studies. Its rigid pyrrolidine backbone and fluorine substitution make it ideal for probing conformational effects, improving metabolic stability, and optimizing bioactivity in drug design. Available in >98% purity (HPLC), this product is rigorously tested for quality and consistency, ensuring reliable performance in synthetic and biochemical applications. Suitable for use in solid-phase peptide synthesis (SPPS), fragment-based drug discovery, and as a building block for bioactive molecules.

Properties

  • CAS Number: 1821782-74-4
  • Complexity: 160
  • IUPAC Name: (2S)-3,3-difluoropyrrolidine-2-carboxylic acid
  • InChI: InChI=1S/C5H7F2NO2/c6-5(7)1-2-8-3(5)4(9)10/h3,8H,1-2H2,(H,9,10)/t3-/m0/s1
  • InChI Key: AKYUQSFIIOIBHO-VKHMYHEASA-N
  • Exact Mass: 151.04448479
  • Molecular Formula: C5H7F2NO2
  • Molecular Weight: 151.11
  • SMILES: C1CN[C@H](C1(F)F)C(=O)O
  • Topological: 49.3
  • Monoisotopic Mass: 151.04448479
  • Synonyms: 1821782-74-4, 3,3-Difluoro-D-proline, (S)-3,3-Difluoropyrrolidine-2-carboxylic acid, 3,3-Difluoropyrrolidine-2beta-carboxylic acid, (2S)-3,3-difluoropyrrolidine-2-carboxylic acid, AT19431

3,3-Difluoro-D-proline is widely used in peptide engineering to enhance stability and modulate secondary structures. It serves as a key intermediate in the synthesis of fluorinated peptidomimetics and protease inhibitors. Researchers leverage its unique conformational properties to study fluorine-induced effects on protein-ligand interactions. This compound is also valuable in NMR and X-ray crystallography for probing molecular dynamics.

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

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Certain molecules may be protected by active patents or regulatory restrictions.

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  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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