Description

2-Fluoro-6-nitroaniline (CAS No. 17809-36-8) is a high-purity aromatic amine derivative with the molecular formula C₆H₅FN₂O₂. This yellow to orange crystalline solid is a valuable intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty dyes. With a molecular weight of 156.12 g/mol, it features both fluoro and nitro functional groups ortho to the amino group, enabling unique reactivity patterns. Our product is rigorously tested for purity (typically ≥98% by HPLC) and is supplied with detailed analytical documentation, including ¹H NMR and GC-MS spectra. Suitable for research and development applications, it is packaged under inert atmosphere in amber glass vials to ensure stability. Hazard classification: H302-H315-H319-H335 (Harmful if swallowed, causes skin/eye irritation, may cause respiratory irritation).

Properties

• CAS Number: 17809-36-8
• Complexity: 159
• IUPAC Name: 2-fluoro-6-nitro-aniline
• InChI: InChI=1S/C6H5FN2O2/c7-4-2-1-3-5(6(4)8)9(10)11/h1-3H,8H2
• InChI Key: BHWHYGWMNMCXBA-UHFFFAOYSA-N
• Exact Mass: 156.03350557
• Molecular Formula: C6H5FN2O2
• Molecular Weight: 156.11
• SMILES: C1=CC(=C(C(=C1)F)N)[N+](=O)[O-]
• Topological: 71.8
• Monoisotopic Mass: 156.03350557
• Synonyms: 2-Fluoro-6-nitroaniline, Benzenamine, 2-fluoro-6-nitro-, 6-Fluoro-2-nitroaniline, EINECS 241-779-9, E347K77NR4, DTXSID90170423, 2-FLUORO-6-NITROBENZENAMINE, DTXCID4092914, 241-779-9, 17809-36-8, 2-Fluoro-6-nitro-phenylamine, MFCD04112583, 2-fluoro-6-nitro-aniline, 2-fluoro-6-nitrophenylamine, SCHEMBL602059, UNII-E347K77NR4, SCHEMBL27650277, 2-amino-3-fluoro-1-nitrobenzene, CS-D0998, BBL101681, SBB051692, STL555477, AKOS006228827, AKOS015967507, AC-2359, AS-8393, SY002839, DB-006133, NS00052450, EN300-106062, Z1201622780

Application

2-Fluoro-6-nitroaniline serves as a key building block in medicinal chemistry for the synthesis of fluorinated quinoline derivatives with potential antibacterial activity. In material science, it is utilized as a precursor for photosensitive polymers and advanced OLED materials. The compound’s electron-withdrawing groups make it particularly useful in palladium-catalyzed cross-coupling reactions for creating complex heterocyclic systems.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.