Description

(R)-2-Amino-1,1,1-trifluoropropane hydrochloride (CAS No. 177469-12-4) is a high-purity chiral amine derivative extensively utilized in pharmaceutical research, agrochemical development, and asymmetric synthesis. With the molecular formula C₃H₇ClF₃N, this compound features a trifluoromethyl group and an amine functionality, making it a valuable building block for the introduction of stereochemical complexity and fluorine motifs in bioactive molecules. Its hydrochloride salt form ensures enhanced stability and solubility for synthetic applications. This product is rigorously tested for purity (typically ≥98% by HPLC or GC) and is available in research quantities with comprehensive analytical data (NMR, MS, HPLC/GC). Ideal for medicinal chemistry, catalysis, and material science, it is supplied in sealed packaging under inert conditions to maintain integrity.

Properties

• CAS Number: 177469-12-4
• Complexity: 57.7
• IUPAC Name: (2R)-1,1,1-trifluoropropan-2-amine;hydrochloride
• InChI: InChI=1S/C3H6F3N.ClH/c1-2(7)3(4,5)6;/h2H,7H2,1H3;1H/t2-;/m1./s1
• InChI Key: VLVCERQEOKPRTG-HSHFZTNMSA-N
• Exact Mass: 149.0219114
• Molecular Formula: C3H7ClF3N
• Molecular Weight: 149.54
• SMILES: C[C@H](C(F)(F)F)N.Cl
• Topological: 26
• Monoisotopic Mass: 149.0219114
• Synonyms: (R)-2-Amino-1,1,1-trifluoropropane hydrochloride, 688-373-1, 177469-12-4, (R)-1,1,1-TRIFLUOROPROPAN-2-AMINE HYDROCHLORIDE, (2R)-1,1,1-trifluoropropan-2-amine hydrochloride, (R)-1,1,1-Trifluoroisopropylamine hydrochloride, 2-Propanamine, 1,1,1-trifluoro-, hydrochloride (1:1), (2R)-, (R)-2-AMINO-1,1,1-TRIFLUOROPROPANE HCL, (2R)-1,1,1-trifluoropropan-2-amine;hydrochloride, MFCD07779095, 2-Propanamine, 1,1,1-trifluoro-, hydrochloride, (2R)-, 4TW3WAD2YF, SCHEMBL2253880, DTXSID90659602, BCP14786, FD2033, AKOS005063313, CS-W006413, AC-25829, DS-13469, (R)-1,1,1-Trifluoropropan-2-amine HCl, DB-001112, EN300-216037, (R)-1-methyl-2,2,2-trifluoroethylamine hydrochloride, 1,1,1-Trifluoropropan-2-amine hydrochloride, (2R)-, (1R)-2,2,2-Trifluoro-1-methylethylamine hydrochloride, (R)-1,1,1-TRIFLUOROPROPAN-2-AMINEHYDROCHLORIDE, (R)-1-methyl-2,2,2-trifluoro-ethylamine hydrochloride, 2-Propanamine, 1,1,1-trifluoro-, hydrochloride, (R)-, (2R)-1,1,1-Trifluoropropan-2-amine–hydrogen chloride (1/1)

This compound serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of protease inhibitors and CNS-active agents. Its chiral nature enables enantioselective transformations, while the trifluoromethyl group enhances metabolic stability in drug candidates. Researchers also employ it in ligand design for asymmetric catalysis and as a precursor for fluorinated agrochemicals. Suitable for nucleophilic substitution, reductive amination, and peptide coupling reactions.

Safety and Hazards

GHS Hazard Statements

• H302+H312+H332 (25%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (25%)
• Skin Irrit. 2 (75%)
• Eye Irrit. 2A (75%)
• STOT SE 3 (75%)

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