Description

2-Methoxy-5-(trifluoromethyl)pyridine (CAS No. 175277-45-9) is a high-purity fluorinated pyridine derivative with the molecular formula C₇H₆F₃NO. This specialized heterocyclic compound features a methoxy group at the 2-position and a trifluoromethyl group at the 5-position of the pyridine ring, offering unique electronic and steric properties for advanced synthetic applications. With a molecular weight of 177.12 g/mol, it is supplied as a clear to pale yellow liquid (or low-melting solid) with ≥95% purity by GC analysis. Ideal for pharmaceutical intermediates, agrochemical research, and materials science, this building block is packaged under inert gas in amber glass vials to ensure stability. Storage at 2-8°C is recommended.

Properties

• CAS Number: 175277-45-9
• Complexity: 148
• IUPAC Name: 2-methoxy-5-(trifluoromethyl)pyridine
• InChI: InChI=1S/C7H6F3NO/c1-12-6-3-2-5(4-11-6)7(8,9)10/h2-4H,1H3
• InChI Key: KNIGTEGBOBDGKP-UHFFFAOYSA-N
• Exact Mass: 177.04014830
• Molecular Formula: C7H6F3NO
• Molecular Weight: 177.12
• SMILES: COC1=NC=C(C=C1)C(F)(F)F
• Topological: 22.1
• Monoisotopic Mass: 177.04014830
• Synonyms: 2-methoxy-5-(trifluoromethyl)pyridine, 175277-45-9, DTXSID10379517, DTXCID70330543, 671-298-3, 2-Methoxy-5-Trifluoromethylpyridine, Pyridine, 2-methoxy-5-(trifluoromethyl)-, MFCD00153203, SCHEMBL706406, SCHEMBL706407, SCHEMBL769126, SCHEMBL4502441, CHEMBL4565654, SCHEMBL21810854, DGEGIRVNNBOXQQ-UHFFFAOYSA-N, ZXTWDBXMBXELGJ-UHFFFAOYSA-N, SBB055546, AKOS005063675, AB04096, AC-9484, CS-W017379, DS-1350, FS-1131, 2-methoxy 5-(trifluoromethyl) pyridine, SY031471, DB-031392, M2832, ST50949988, EN300-157074, H10035

Application

2-Methoxy-5-(trifluoromethyl)pyridine serves as a key intermediate in the synthesis of bioactive molecules, particularly in pharmaceutical and agrochemical research. Its electron-deficient pyridine core and trifluoromethyl group make it valuable for designing kinase inhibitors and CNS-active compounds. The compound is also utilized in ligand synthesis for catalytic systems and as a fluorinated building block in material science applications.

Safety and Hazards

GHS Hazard Statements

• H226 (66.7%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (66.7%)
• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.