Description

2-Bromo-3-(trifluoromethyl)pyridine (CAS No. 175205-82-0) is a high-purity, halogenated pyridine derivative designed for advanced research and industrial applications. With the molecular formula C₆H₃BrF₃N, this compound features a bromine substituent at the 2-position and a trifluoromethyl group at the 3-position of the pyridine ring, offering unique reactivity and versatility in synthetic chemistry. It is available in 97% purity, ensuring optimal performance in pharmaceutical, agrochemical, and materials science research. Packaged under inert conditions to maintain stability, this reagent is ideal for cross-coupling reactions, nucleophilic substitutions, and as a building block for fluorinated heterocycles. Suitable for use in HPLC, GC-MS, and NMR analysis, it is a critical tool for chemists and researchers.

Properties

• CAS Number: 175205-82-0
• Complexity: 136
• IUPAC Name: 2-bromo-3-(trifluoromethyl)pyridine
• InChI: InChI=1S/C6H3BrF3N/c7-5-4(6(8,9)10)2-1-3-11-5/h1-3H
• InChI Key: OFGSIPQYQUVVPL-UHFFFAOYSA-N
• Exact Mass: 224.94010
• Molecular Formula: C6H3BrF3N
• Molecular Weight: 225.99
• SMILES: C1=CC(=C(N=C1)Br)C(F)(F)F
• Topological: 12.9
• Monoisotopic Mass: 224.94010
• Synonyms: 2-Bromo-3-(trifluoromethyl)pyridine, 625-765-3, 175205-82-0, 2-bromo-3-trifluoromethylpyridine, Pyridine, 2-bromo-3-(trifluoromethyl)-, MFCD00153084, 2-Bromo-3-Trifluoromethyl Pyridine, SCHEMBL162911, DTXSID70409349, 2-Bromo-3-trifluoromethyl-pyridine, BBL100875, RB1731, SBB054385, STL554669, AKOS005063454, 2-bromanyl-3-(trifluoromethyl)pyridine, AB04059, AC-9469, CS-W013033, PS-7770, 2-Bromo-3-(trifluoromethyl)pyridine, 97%, DB-005996, B3179, EN300-118946, A811956

2-Bromo-3-(trifluoromethyl)pyridine is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its reactive bromine and electron-withdrawing trifluoromethyl group make it valuable in Suzuki-Miyaura and Stille cross-coupling reactions. This compound is also employed in the development of ligands, catalysts, and specialty materials due to its structural versatility. Researchers leverage its properties for constructing complex heterocycles in drug discovery programs.

Safety and Hazards

GHS Hazard Statements

• H228 (89.1%): Flammable solid [Danger Flammable solids]
• H300 (89.1%): Fatal if swallowed [Danger Acute toxicity, oral]
• H315 (97.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (87%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (10.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P240, P241, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Sol. 2 (89.1%)
• Acute Tox. 2 (89.1%)
• Skin Irrit. 2 (97.8%)
• Eye Dam. 1 (87%)
• Eye Irrit. 2 (10.9%)
• STOT SE 3 (95.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.