Description

gamma-Cyclodextrin (γ-CD) is a cyclic oligosaccharide composed of eight α-1,4-linked D-glucopyranose units, forming a toroidal structure with a hydrophilic outer surface and a hydrophobic central cavity. This unique molecular architecture enables γ-CD to form inclusion complexes with a wide range of guest molecules, enhancing solubility, stability, and bioavailability. With a molecular formula of C₄₈H₈₀O₄₀ (CAS No. 17465-86-0), γ-CD is widely utilized in pharmaceutical formulations, food additives, and chemical research due to its non-toxic, biodegradable, and biocompatible properties. Our high-purity γ-CD (≥98% by HPLC) is rigorously tested for quality and consistency, making it ideal for applications requiring precise molecular encapsulation and controlled release.

Available in powder form, this product is produced under strict manufacturing standards to ensure low endotoxin levels and suitability for cell culture and analytical applications. Its superior complexation capacity compared to α- and β-cyclodextrins makes it invaluable for solubilizing hydrophobic compounds, stabilizing sensitive actives, and masking undesirable odors or flavors in industrial formulations.

Properties

• CAS Number: 17465-86-0
• Complexity: 1720
• IUPAC Name: (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36S,38R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R,50R,51R,52R,53R,54R,55R,56R)-5,10,15,20,25,30,35,40-octakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo[36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36]hexapentacontane-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecol
• InChI: InChI=1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1
• InChI Key: GDSRMADSINPKSL-HSEONFRVSA-N
• Exact Mass: 1296.4225873
• Molecular Formula: C48H80O40
• Molecular Weight: 1297.1
• SMILES: C([C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7O)O)O[C@@H]8[C@H](O[C@@H]([C@@H]([C@H]8O)O)O[C@@H]9[C@H](O[C@H](O2)[C@@H]([C@H]9O)O)CO)CO)CO)CO)CO)CO)CO)O)O)O
• Topological: 633
• Monoisotopic Mass: 1296.4225873
• Physical Description: White to nearly white solid; Virtually odorless; White powder;
• Synonyms: gamma-Cyclodextrin, Cyclooctaamylose, gamma cyclodextrin, Cyclooctapentylose, .gamma.-Cyclodextrin, g-cyclodextrin, UNII-KZJ0BYZ5VA, Gamma cyclodextrin [NF], DTXSID5047033, EINECS 241-482-4, GAMMA CYCLODEXTRIN [II], DTXCID3027033, GAMMA-CYCLODEXTRIN [FCC], EC 241-482-4, .GAMMA.-CYCLODEXTRIN [MI], GAMMA CYCLODEXTRIN [MART.], GAMMA CYCLODEXTRIN [USP-RS], ALFADEX IMPURITY B [EP IMPURITY], Schardinger gamma-Dextrin, GAMMA CYCLODEXTRIN (II), CYCLOOCTAKIS-(1->4)-(.ALPHA.-D-GLUCOPYRANOSYL), GAMMA CYCLODEXTRIN (MART.), GAMMA CYCLODEXTRIN (USP-RS), ALFADEX IMPURITY B (EP IMPURITY), gammaDextrin, gammaCD, cyclomalto-octaose, Cyclooctakis-(1->4)-(a-D-glucopyranose), Dexy Pearl gamma100, Schardinger gammaDextrin, 5,10,15,20,25,30,35,40-octakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo(36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36)hexapentacontane-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecol, 5,10,15,20,25,30,35,40-octakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo[36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36]hexapentacontane-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecol, CYCLOOCTAKIS-(1->4)-(ALPHA-D-GLUCOPYRANOSYL), (1s,5r,6s,10r,11s,15r,16s,20r,21s,25r,26s,30r,31s,35r,36s,40r,41r,42r,43r,44r,45r,46r,47r,48r,49r,50r,51r,52r,53r,54r,55r,56r)-5,10,15,20,25,30,35,40-octakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo(36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36)hexapentacontane-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecol, (1s,5r,6s,10r,11s,15r,16s,20r,21s,25r,26s,30r,31s,35r,36s,40r,41r,42r,43r,44r,45r,46r,47r,48r,49r,50r,51r,52r,53r,54r,55r,56r)-5,10,15,20,25,30,35,40-octakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo[36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36]hexapentacontane-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecol, 17465-86-0, Cyclomaltooctaose, Ringdex C, gamma-Dextrin, gamma-CD, Cavamax w8, Cyclodextrin, gamma-, KZJ0BYZ5VA, Ins no.458, MFCD00009595, Ins-458, CHEBI:495056, E-458, Gammacyclodextrin, |A-?Cyclodextrin, gamma -Cyclodextrin, Schardinger ?-Dextrin, 1p2g, SCHEMBL8768, gamma-Cyclodextrin, >=98%, CHEMBL3182126, BDBM36126, Tox21_302303, MSK170159, AKOS037643646, CS-W020780, HY-W040040, NCGC00256143-01, AS-19609, CAS-17465-86-0, F15410, gamma-Cyclodextrin, purum, >=98.0% (HPLC), Q27225754, Gamma Cyclodextrin, United States Pharmacopeia (USP) Reference Standard, gamma-Cyclodextrin, powder, BioReagent, suitable for cell culture, >=98%, Cyclomaltooctaose, Cyclooctaamylose, Schardinger gamma-Dextrin, gamma-Cyclodextrin, gamma-Cyclodextrin, produced by Wacker Chemie AG, Burghausen, Germany, >=90.0% cyclodextrin basis (HPLC), gamma-Cyclodextrin, produced by Wacker Chemie AG, Burghausen, Germany, >=98% (on dry basis), gamma-Cyclodextrin, Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.0-102.0% cyclodextrin basis

gamma-Cyclodextrin is extensively used in pharmaceuticals to improve drug solubility and bioavailability through host-guest complexation. In food science, it serves as a flavor stabilizer and carrier for fragrances or nutraceuticals. Its cavity size (∼9.2 Å diameter) accommodates larger molecules than α- or β-cyclodextrins, enabling applications in environmental remediation for pollutant capture. Researchers also employ γ-CD in chromatography as a chiral selector and in nanotechnology for controlled release systems.

Safety and Hazards

GHS Hazard Statements

• Not Classified
• Reported as not meeting GHS hazard criteria by 109 of 120 companies (only 9.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Hazard Classes and Categories

• Not Classified

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