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Atomfair 3-Fluorophenylmagnesium Bromide C6H4BrFMg CAS 17318-03-5

3-Fluorophenylmagnesium Bromide (CAS No. 17318-03-5) is a highly reactive Grignard reagent with the molecular formula C6H4BrFMg . This organomagnesium compound is widely used in synthetic organic chemistry for the introduction of the 3-fluorophenyl group into various substrates. Supplied as a solution in diethyl ether or THF (typically 0.5M to 1.0M concentration), it offers excellent reactivity for nucleophilic additions to carbonyl compounds, epoxides, and other electrophiles. The reagent is moisture- and air-sensitive, requiring handling under inert atmosphere conditions. Ideal for pharmaceutical intermediates, material science research, and fine chemical synthesis. Key specifications include: IUPAC Name: magnesium;fluorobenzene;bromide Appearance: Clear to slightly yellow solution…

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Description

3-Fluorophenylmagnesium Bromide (CAS No. 17318-03-5) is a highly reactive Grignard reagent with the molecular formula C6H4BrFMg. This organomagnesium compound is widely used in synthetic organic chemistry for the introduction of the 3-fluorophenyl group into various substrates. Supplied as a solution in diethyl ether or THF (typically 0.5M to 1.0M concentration), it offers excellent reactivity for nucleophilic additions to carbonyl compounds, epoxides, and other electrophiles. The reagent is moisture- and air-sensitive, requiring handling under inert atmosphere conditions. Ideal for pharmaceutical intermediates, material science research, and fine chemical synthesis.

Key specifications include:

  • IUPAC Name: magnesium;fluorobenzene;bromide
  • Appearance: Clear to slightly yellow solution
  • Concentration: Typically 0.5M in diethyl ether or THF
  • Storage: 2-8°C under inert gas
  • Purity: ≥95% (by titration)

Properties

  • CAS Number: 17318-03-5
  • Complexity: 149
  • IUPAC Name: magnesium;fluorobenzene;bromide
  • InChI: InChI=1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h1-2,4-5H;1H;/q-1;;+2/p-1
  • InChI Key: DTKMKZYEOXZPQZ-UHFFFAOYSA-M
  • Exact Mass: 197.93308
  • Molecular Formula: C6H4BrFMg
  • Molecular Weight: 199.30
  • SMILES: C1=C[C-]=CC(=C1)F.[Mg+2].[Br-]
  • Monoisotopic Mass: 197.93308
  • Synonyms: 3-FLUOROPHENYLMAGNESIUM BROMIDE, 627-049-6, 17318-03-5, Magnesium, bromo(3-fluorophenyl)-, bromo(3-fluorophenyl)magnesium, 3-Fluorophenylmagnesiumbromide, 3-Fluorophenylmagnesium bromide, 0.5M in THF, 3-Fluorophenylmagnesium bromide, 1.0 M in THF, 3-flurophenylmagnesiumbromide, SCHEMBL37679, 3-flurophenyl magnesium bromide, 3-fluorophenyl magnesium bromide, 3-Fluorophenyl-magnesium bromide, (3-fluorophenyl)magnesium bromide, VFPDAAQAKDGSHQ-UHFFFAOYSA-M, AKOS015890800, 3-Fluorophenylmagnesium bromide 1M in THF, 3-Fluorophenylmagnesium bromide, 1.0 M in 2-MeTHF, 3-Fluorophenylmagnesium bromide 0.5 M in Tetrahydrofuran

Application

3-Fluorophenylmagnesium Bromide is primarily used as a versatile building block in organic synthesis. It serves as a key reagent for the preparation of fluorinated pharmaceutical intermediates through nucleophilic addition reactions. The compound finds particular utility in the synthesis of bioactive molecules containing 3-fluorophenyl moieties. Researchers also employ this Grignard reagent in material science for modifying aromatic systems in advanced materials.

Safety and Hazards

GHS Hazard Statements

  • H225 (43.5%): Highly Flammable liquid and vapor [Danger Flammable liquids]
  • H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

  • P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501

Hazard Classes and Categories

  • Flam. Liq. 2 (43.5%)
  • Skin Corr. 1B (100%)

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Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

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