Description

Methyl 2,3-dibromopropionate (CAS No. 1729-67-5) is a high-purity brominated ester with the molecular formula C₄H₆Br₂O₂, widely utilized in organic synthesis and pharmaceutical research. This compound, also known as methyl 2,3-dibromopropanoate, is characterized by its clear to pale yellow liquid appearance and distinct brominated ester properties. With a molecular weight of 245.90 g/mol, it serves as a versatile intermediate for nucleophilic substitution reactions, cyclopropanation, and the synthesis of bioactive molecules. Ideal for researchers requiring precise bromination agents, this product is rigorously tested for purity and stability, ensuring consistent performance in demanding laboratory applications. Packaged under inert conditions to maintain integrity, it is a critical reagent for advanced chemical transformations.

Properties

• CAS Number: 1729-67-5
• Complexity: 84.1
• IUPAC Name: methyl 2,3-dibromopropanoate
• InChI: InChI=1S/C4H6Br2O2/c1-8-4(7)3(6)2-5/h3H,2H2,1H3
• InChI Key: ROXQOUUAPQUMLN-UHFFFAOYSA-N
• Exact Mass: 245.87141
• Molecular Formula: C4H6Br2O2
• Molecular Weight: 245.90
• SMILES: COC(=O)C(CBr)Br
• Topological: 26.3
• Monoisotopic Mass: 243.87345
• Physical Description: Clear colorless liquid;
• Synonyms: Methyl 2,3-dibromopropionate, Methyl 2,3-dibromopropanoate, 1729-67-5, Propanoic acid, 2,3-dibromo-, methyl ester, Caswell No. 561, Propionic acid, 2,3-dibromo-, methyl ester, UNII-69GU2PIR6V, 69GU2PIR6V, Methyl .alpha.,.beta.-dibromopropionate, DTXSID2042145, NSC 9372, NSC-9372, EINECS 217-044-3, EPA Pesticide Chemical Code 077706, AI3-50603, DTXCID0022145, NSC-372, 2,3-DIBROMOPROPANOIC ACID METHYL ESTER, 2,3-DIBROMOPROPIONIC ACID METHYL ESTER, Methyl alpha,beta-dibromopropionate, Methyl 2,3dibromopropanoate, Propanoic acid, 2,3dibromo, methyl ester, Propionic acid, 2,3dibromo, methyl ester, Propionic acid, 2,3dibromo, methyl ester (8CI), Propionic acid, 2,3-dibromo-, methyl ester (8CI), (+-)-2,3-DIBROMOPROPIONIC ACID METHYL ESTER, 217-044-3, inchi=1/c4h6br2o2/c1-8-4(7)3(6)2-5/h3h,2h2,1h, roxqouuapqumln-uhfffaoysa-n, MFCD00017882, Methyl2,3-dibromopropanoate, SCHEMBL296242, methyl 2,3-dibro-mopropanoate, SCHEMBL7661125, CHEMBL3183093, NSC9372, Tox21_301977, AB2902, AKOS000121389, AKOS022181546, Methyl 2 pound not3-Dibromopropionate, 2,3-dibromo-propionic acid methyl ester, NCGC00255961-01, Propanoic acid,3-dibromo-, methyl ester, Propionic acid,3-dibromo-, methyl ester, AS-44668, CAS-1729-67-5, CS-0187461, M3182, NS00025666, EN300-16660, Methyl 2,3-dibromopropionate, >=97.0% (GC), (+/-)-2,3-DIBROMOPROPIONIC ACID METHYL ESTER, Q27264348

Application

Methyl 2,3-dibromopropionate is primarily employed as a key intermediate in the synthesis of cyclopropane derivatives and other strained ring systems. It is also used in pharmaceutical research for the preparation of brominated analogs of bioactive compounds. Additionally, this reagent finds application in polymer chemistry as a crosslinking agent or modifier for specialty resins. Its reactivity with nucleophiles makes it valuable for constructing complex molecular architectures in organic synthesis.

Safety and Hazards

GHS Hazard Statements

• H315 (11.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (90.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (11.1%)
• Eye Irrit. 2 (98.1%)
• STOT SE 3 (90.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.