Description

Ethyl 4-hydroxyphenylacetate (CAS No. 17138-28-2) is a high-purity organic compound with the molecular formula C₁₀H₁₂O₃. This ester derivative of 4-hydroxyphenylacetic acid is widely utilized in pharmaceutical, fragrance, and fine chemical synthesis due to its versatile reactivity and stable phenolic ester structure. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC), with stringent control of residual solvents and heavy metals for research and industrial applications. Available in quantities from grams to bulk kilograms, it is supplied in amber glass bottles or sealed drums under inert gas to prevent degradation. Ideal for use as a synthetic intermediate, reference standard, or biochemical reagent.

Properties

• CAS Number: 17138-28-2
• Complexity: 160
• IUPAC Name: ethyl 2-(4-hydroxyphenyl)acetate
• InChI: InChI=1S/C10H12O3/c1-2-13-10(12)7-8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3
• InChI Key: HYUPPKVFCGIMDB-UHFFFAOYSA-N
• Exact Mass: 180.078644241
• Molecular Formula: C10H12O3
• Molecular Weight: 180.20
• SMILES: CCOC(=O)CC1=CC=C(C=C1)O
• Topological: 46.5
• Monoisotopic Mass: 180.078644241
• Synonyms: Ethyl 4-hydroxyphenylacetate, ethyl 2-(4-hydroxyphenyl)acetate, Benzeneacetic acid, 4-hydroxy-, ethyl ester, 4-Hydroxyphenylacetic acid ethyl ester, ethyl (4-hydroxyphenyl)acetate, Ethyl (p-hydroxyphenyl)acetate, 94NWB742CW, EINECS 241-197-5, DTXSID0066165, Acetic acid, (p-hydroxyphenyl)-, ethyl ester, (4-Hydroxy-phenyl)-acetic acid ethylester, DTXCID2035487, Ethyl 2-(4-hydroxyphenyl)acetic acid, 241-197-5, ethyl 4-hydroxyphenylacetic acid, hyuppkvfcgimdb-uhfffaoysa-n, inchi=1/c10h12o3/c1-2-13-10(12)7-8-3-5-9(11)6-4-8/h3-6,11h,2,7h2,1h, 17138-28-2, MFCD00016491, ETHYL-4-HYDROXYPHENYLACETATE, Ethyl p-hydroxyphenylacetate, P-Hydroxyphenyl Acetic Acid Ethyl Ester, UNII-94NWB742CW, ethyl (4hydroxyphenyl)acetate, SCHEMBL1179218, SCHEMBL5545889, AKOS000280327, CS-W017199, FE23013, HY-W016483, 4-hydroxy-phenylacetic acid ethyl ester, 4-hydroxyphenyl acetic acid ethyl ester, AS-10794, SY015387, (4-hydroxy-phenyl)-acetic acid ethyl ester, DB-023047, E1034, NS00025628, ST50407272, EN300-49188, Q67879878, F0001-0623, 4-Hydroxyphenylacetic acid ethyl ester;4-Hydroxybenzeneacetic acid ethyl ester;(p-Hydroxyphenyl)acetic acid ethyl ester

Application

Ethyl 4-hydroxyphenylacetate serves as a key intermediate in the synthesis of pharmaceuticals, including non-steroidal anti-inflammatory drugs (NSAIDs) and fragrance compounds. It is employed in organic synthesis for introducing the 4-hydroxyphenylacetyl moiety into target molecules. Researchers also utilize it as a precursor for studying enzymatic ester hydrolysis or as a standard in analytical chromatography.

Safety and Hazards

GHS Hazard Statements

• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (75%)
• Eye Irrit. 2A (75%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.