Description

4,4′-Trimethylenedipiperidine (CAS No. 16898-52-5) is a high-purity organic compound with the molecular formula C₁₃H₂₆N₂. This bifunctional piperidine derivative, also known by its IUPAC name 4-(3-piperidin-4-ylpropyl)piperidine, features a trimethylene spacer linking two piperidine rings, making it a valuable building block in medicinal chemistry and materials science. With a molecular weight of 210.36 g/mol, this compound is typically supplied as a colorless to pale-yellow liquid or low-melting solid, depending on storage conditions.

Our product is rigorously tested to ensure ≥98% purity (GC) and is packaged under inert atmosphere to guarantee stability. It is soluble in common organic solvents such as ethanol, methanol, and dichloromethane, but exhibits limited water solubility. Researchers will appreciate the compound’s versatility as a precursor for pharmaceutical intermediates, ligand synthesis, and polymer modification. Each batch is accompanied by comprehensive analytical data including ¹H NMR, ¹³C NMR, and HPLC chromatograms.

Key synonyms include: 1,3-Bis(4-piperidyl)propane, 1,3-Di-4-piperidylpropane, and Piperidine, 4,4′-(1,3-propanediyl)bis-. Proper storage recommendations: maintain at 2-8°C in tightly sealed containers under nitrogen atmosphere. Hazard classification: Irritant (GHS07).

Properties

• CAS Number: 16898-52-5
• Complexity: 140
• IUPAC Name: 4-[3-(4-piperidyl)propyl]piperidine
• InChI: InChI=1S/C13H26N2/c1(2-12-4-8-14-9-5-12)3-13-6-10-15-11-7-13/h12-15H,1-11H2
• InChI Key: OXEZLYIDQPBCBB-UHFFFAOYSA-N
• Exact Mass: 210.209598838
• Molecular Formula: C13H26N2
• Molecular Weight: 210.36
• SMILES: C1CNCCC1CCCC2CCNCC2
• Topological: 24.1
• Monoisotopic Mass: 210.209598838
• Physical Description: Other Solid
• Synonyms: 1,3-Bis(4-piperidyl)propane, 16898-52-5, 4,4′-Trimethylenedipiperidine, 1,3-Di-4-piperidylpropane, Piperidine, 4,4′-(1,3-propanediyl)bis-, Piperidine, 4,4′-trimethylenedi-, 4,4′-(1,3-Propanediyl)bispiperidine, EU53EC219I, EINECS 240-941-6, NSC 96364, NSC-96364, AI3-61833, Piperidine, 4,4′-trimethylenedi-(8CI), 240-941-6, DI-PIP, 1,3-Di(4-Piperidyl)propane, 4-[3-(piperidin-4-yl)propyl]piperidine, 4-[3-(4-piperidyl)propyl]piperidine, 4-(3-piperidin-4-ylpropyl)piperidine, 1,3-di(piperidin-4-yl)propane, 1,3-bis(4-piperidinyl)propane, MFCD00038013, 4,4′-Propane-1,3-diyldipiperidine, 4-(3-(4-piperidyl)propyl)piperidine, 4,4′-(1,3-Propanediyl)bis(piperidine), 4,4′-(1,3-Propanediyl)bis[piperidine], UNII-EU53EC219I, NSC96364, Maybridge4_003634, Oprea1_445285, 4,3-Propanediyl)bispiperidine, CHEMBL10749, Piperidine,4′-trimethylenedi-, SCHEMBL237382, SCHEMBL2014329, SCHEMBL7138787, DTXSID6044850, SCHEMBL11636554, OXEZLYIDQPBCBB-UHFFFAOYSA-, HMS1531F04, STR05333, SBB057893, 4,4′-Trimethylenedipiperidine, 97%, AKOS000120146, 4,4′-(1,3-propane-diyl)dipiperidine, CCG-245116, Piperidine,4′-(1,3-propanediyl)bis-, SB43113, ST095685, SY020011, 4-[3-(4-Piperidinyl)propyl]piperidine #, D0293, NS00025547, EN300-20616, D97682, Q27277371, F0001-0617, Z104479250, InChI=1/C13H26N2/c1(2-12-4-8-14-9-5-12)3-13-6-10-15-11-7-13/h12-15H,1-11H2

Application

4,4′-Trimethylenedipiperidine serves as a crucial scaffold in the development of pharmaceutical compounds, particularly in creating novel dopamine receptor modulators and enzyme inhibitors. The compound’s rigid yet flexible structure makes it valuable for constructing chelating ligands in coordination chemistry and catalysis. Researchers also utilize this diamine in polymer science to modify epoxy resins and polyurethane systems, enhancing thermal stability and mechanical properties.

Safety and Hazards

GHS Hazard Statements

• H302 (42%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (14.5%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (85.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (21.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (78.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (81.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H412 (14.5%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (42%)
• Skin Corr. 1C (14.5%)
• Skin Irrit. 2 (85.5%)
• Eye Dam. 1 (21.7%)
• Eye Irrit. 2 (78.3%)
• STOT SE 3 (81.2%)
• Aquatic Chronic 3 (14.5%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.