Description

4-Amino-2,3,5,6-tetrafluoropyridine (CAS No. 1682-20-8) is a high-purity fluorinated pyridine derivative with the molecular formula C₅H₂F₄N₂. This compound, also known by its IUPAC name 2,3,5,6-tetrafluoropyridin-4-amine, is a versatile building block in organic synthesis and pharmaceutical research. Its unique tetrafluorinated structure enhances reactivity and stability, making it ideal for nucleophilic aromatic substitution reactions and the development of advanced materials. Suitable for researchers and scientists, our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied in sealed, light-resistant packaging under inert conditions to maintain integrity. Available in quantities ranging from milligrams to kilograms, it is perfect for lab-scale experiments and industrial applications.

Properties

• CAS Number: 1682-20-8
• Complexity: 130
• IUPAC Name: 2,3,5,6-tetrafluoropyridin-4-amine
• InChI: InChI=1S/C5H2F4N2/c6-1-3(10)2(7)5(9)11-4(1)8/h(H2,10,11)
• InChI Key: PLVFNMQHMRRBAA-UHFFFAOYSA-N
• Exact Mass: 166.01541072
• Molecular Formula: C5H2F4N2
• Molecular Weight: 166.08
• SMILES: C1(=C(C(=NC(=C1F)F)F)F)N
• Topological: 38.9
• Monoisotopic Mass: 166.01541072
• Synonyms: 4-Amino-2,3,5,6-tetrafluoropyridine, 1682-20-8, DTXSID60361523, DTXCID80312572, 623-682-7, 2,3,5,6-tetrafluoropyridin-4-amine, 4-aminotetrafluoropyridine, 4-Pyridinamine, 2,3,5,6-tetrafluoro-, 2,3,5,6-tetrafluoro-4-pyridylamine, tetrafluoropyridin-4-amine, C5H2F4N2, MFCD00010855, SCHEMBL1002200, SBB028360, AKOS005063368, SB52492, SDCCGMLS-0064535.P001, 2,3,5,6-tetrafluoro-pyridin-4-ylamine, AS-48021, ST029285, DB-001281, A1546, CS-0157955, 4-Amino-2,3,5,6-tetrafluoropyridine, 98%, F17553, 4-Aminotetrafluoropyridine;4-Amino-2,3,5,6-tetrafluoropyridine

Application

4-Amino-2,3,5,6-tetrafluoropyridine is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals, agrochemicals, and specialty materials. Its electron-deficient pyridine ring facilitates selective functionalization, enabling the creation of novel heterocyclic compounds. Researchers employ it in cross-coupling reactions and as a precursor for ligands in catalysis. The compound’s fluorine-rich structure also contributes to the development of bioactive molecules with enhanced metabolic stability and membrane permeability.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (91.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (91.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (91.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (91.3%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.