Description

4-Chlorophenylboronic Acid (CAS No. 1679-18-1) is a high-purity boronic acid derivative with the molecular formula C₆H₆BClO₂. This white to off-white crystalline powder is widely used in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, due to its excellent reactivity and stability. With a purity of ≥95%, it is ideal for pharmaceutical, agrochemical, and materials science research. The compound is moisture-sensitive and should be stored under inert conditions to maintain its integrity. Its well-defined structure and consistent performance make it a preferred choice for researchers requiring precise boronic acid intermediates.

Key Features:

• High reactivity in cross-coupling reactions
• Suitable for pharmaceutical and material science applications
• Stable under recommended storage conditions
• Available in various packaging sizes to meet lab-scale and bulk requirements

Properties

• CAS Number: 1679-18-1
• Complexity: 102
• IUPAC Name: (4-chlorophenyl)boronic acid
• InChI: InChI=1S/C6H6BClO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H
• InChI Key: CAYQIZIAYYNFCS-UHFFFAOYSA-N
• Exact Mass: 156.0149373
• Molecular Formula: C6H6BClO2
• Molecular Weight: 156.38
• SMILES: B(C1=CC=C(C=C1)Cl)(O)O
• Topological: 40.5
• Monoisotopic Mass: 156.0149373
• Synonyms: 4-Chlorophenylboronic acid, 1679-18-1, (4-chlorophenyl)boronic acid, p-Chlorophenylboronic acid, Boronic acid, (4-chlorophenyl)-, p-Chlorobenzeneboronic acid, Benzeneboronic acid, p-chloro-, Boronic acid, p-chlorophenyl, (p-Chlorophenyl)metaboric acid, NSC 25408, EINECS 216-845-5, AB2T8N4T4C, BRN 2936346, AI3-32764, (P-CHLOROPHENYL)BORONIC ACID, NSC-25408, 4-16-00-01667 (Beilstein Handbook Reference), DTXSID50168427, B-(4-CHLOROPHENYL)BORONIC ACID, BORONIC ACID, B-(4-CHLOROPHENYL)-, DTXCID0090918, 216-845-5, 4-Chlorobenzeneboronic acid, MFCD00039137, 4-chlorophenyl boronic acid, 4-chloro-phenylboronic acid, (4-chloro-phenyl)-boronic acid, [4-chloro-phenyl]-boronic acid, 4-Chlorophenylboronicacid, 4-chloro phenyl boronic acid, B-(4-CHLOROPHENYL)-BORONIC ACID, 4chlorophenylboronic acid, Phenylboronic acid, 18, 4-chlorophenyboronic acid, 4-chlorphenylboronic acid, 4-chorophenylboronic acid, WLN: QBQR DG, 4chlorophenyl boronic acid, p-chloro phenylboronic acid, p-chlorophenyl boronic acid, UNII-AB2T8N4T4C, (4-chlorophenyl)boronicacid, 4-chlorophenyl-boronic acid, para-chlorophenylboronic acid, 4-chloro-benzeneboronic acid, 4-chlorobenzene boronic acid, SCHEMBL28166, 4- chlorophenyl boronic acid, 4-chloro-phenyl boronic acid, 4-chloro benzene boronic acid, AKOS BRN-0011, (4-chloro-phenyl)boronic acid, (4-chlorophenyl) boronic acid, (4-chlorophenyl)dihydroxyborane, CHEMBL1209679, BDBM92725, 4-Chlorophenylboronic acid, 95%, ALBB-006093, BCP22737, CS-D1133, NSC25408, SBB048060, STK503701, AKOS000121904, AB01763, AC-3320, AS-2333, BCP9000258, FC08281, NCGC00249500-01, SY004529, DB-031707, NS00025512, EN300-29827, F9995-0588, Z295122658, 4-Chlorophenylboronic Acid (contains varying amounts of Anhydride), 4-Chlorophenylboronic acid(contains varying amounts of Anhydride)

4-Chlorophenylboronic acid is primarily used as a key intermediate in Suzuki-Miyaura cross-coupling reactions to form biaryl compounds, essential in drug discovery and material science. It serves as a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and organic electronic materials. Researchers also utilize it in the development of sensors and catalysts due to its boronic acid functionality.

Safety and Hazards

GHS Hazard Statements

• H302 (77.4%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (71%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (19.4%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (19.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (71%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (17.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (77.4%)
• Acute Tox. 4 (71%)
• Skin Irrit. 2 (19.4%)
• Eye Irrit. 2 (19.4%)
• Acute Tox. 4 (71%)
• STOT SE 3 (17.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.