Description

6-Chloro-2-fluoropurine (CAS No. 1651-29-2) is a high-purity fluorinated purine derivative with the molecular formula C₅H₂ClFN₄. This heterocyclic compound, also known by its IUPAC name 6-chloro-2-fluoro-7H-purine, is a valuable intermediate in pharmaceutical and biochemical research. Its unique structure, featuring both chloro and fluoro substituents on the purine scaffold, makes it a versatile building block for nucleoside analogs and other bioactive molecules. Our product is rigorously tested to ensure ≥95% purity (HPLC) and is supplied as a white to off-white crystalline powder. Suitable for use in medicinal chemistry, drug discovery, and as a precursor for further functionalization. Store in a cool, dry place at 2-8°C under inert atmosphere.

Properties

• CAS Number: 1651-29-2
• Complexity: 157
• IUPAC Name: 6-chloro-2-fluoro-7H-purine
• InChI: InChI=1S/C5H2ClFN4/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H,8,9,10,11)
• InChI Key: UNRIYCIDCQDGQE-UHFFFAOYSA-N
• Exact Mass: 171.9952019
• Molecular Formula: C5H2ClFN4
• Molecular Weight: 172.55
• SMILES: C1=NC2=C(N1)C(=NC(=N2)F)Cl
• Topological: 54.5
• Monoisotopic Mass: 171.9952019
• Synonyms: 6-CHLORO-2-FLUOROPURINE, 1651-29-2, 6-Chloro-2-fluoro-9H-purine, 726CLW3V39, 6-chloranyl-2-fluoranyl-7H-purine, NSC-37363, UNII-726CLW3V39, DTXSID80415330, NSC 37363, DTXCID30366181, 634-083-5, 6-chloro-2-fluoro-7H-purine, 2-Fluoro-6-chloropurine, 9H-Purine, 6-chloro-2-fluoro-, MFCD02183557, C5H2ClFN4, 1jdj, 2-fluoro,6-chloro-purine, 2-fluoro-6-chloro-purine, 6-chloro-2-fluoro-purine, CFP, SCHEMBL356177, SCHEMBL356178, 6-Chloro-2-fluoropurine, 97%, BCP30954, NSC37363, BBL100449, MFCD08461765, SBB054665, STL554243, 6-chloro-2-fluoropurine, AldrichCPR, AKOS005063531, AKOS005254438, CS-W002924, DB03520, FC03333, HY-W002924, PS-6852, AC-23432, PD039170, SY018648, DB-001321, C2221, NS00070313, EN300-761520, Z1741959673

Application

6-Chloro-2-fluoropurine serves as a key synthetic intermediate in the preparation of modified nucleosides and nucleotides with potential antiviral or anticancer activity. Researchers utilize this compound to study structure-activity relationships in purine-based therapeutics. It’s particularly valuable for introducing fluorine atoms into bioactive molecules to modulate their pharmacokinetic properties. The chloro substituent allows for further selective functionalization via cross-coupling reactions.

Safety and Hazards

GHS Hazard Statements

• H302 (98.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (92%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (99.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (98.2%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (92%)
• STOT SE 3 (99.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.