Description

5-Bromo-4-cyclopropyl-6-methoxypyrimidine (CAS No. 1649454-57-8) is a high-purity heterocyclic compound with the molecular formula C₈H₉BrN₂O. This brominated pyrimidine derivative features a cyclopropyl substituent and a methoxy group, making it a valuable intermediate in pharmaceutical and agrochemical synthesis. Its precise molecular structure ensures optimal reactivity for cross-coupling reactions, nucleophilic substitutions, and other functionalizations. Suitable for research and development, this compound is rigorously tested for quality (≥95% purity by HPLC) and supplied in secure, light-resistant packaging to ensure stability. Ideal for medicinal chemistry, drug discovery, and material science applications.

Properties

• CAS Number: 1649454-57-8
• Complexity: 163
• IUPAC Name: 5-bromo-4-cyclopropyl-6-methoxy-pyrimidine
• InChI: InChI=1S/C8H9BrN2O/c1-12-8-6(9)7(5-2-3-5)10-4-11-8/h4-5H,2-3H2,1H3
• InChI Key: FHEYKQYHQQAZBJ-UHFFFAOYSA-N
• Exact Mass: 227.98983
• Molecular Formula: C8H9BrN2O
• Molecular Weight: 229.07
• SMILES: COC1=NC=NC(=C1Br)C2CC2
• Topological: 35
• Monoisotopic Mass: 227.98983
• Synonyms: 5-BROMO-4-CYCLOPROPYL-6-METHOXYPYRIMIDINE, 1649454-57-8, MFCD31556944, 5-bromo-4-cyclopropyl-6-methoxy-pyrimidine, SCHEMBL16441705, AKOS037645960, AS-65214, SY291995, DB-168713, CS-0377130, 5-bromo-4-cyclopropyl-6-methoxypyrimidine(WX192148)

Application

5-Bromo-4-cyclopropyl-6-methoxypyrimidine serves as a versatile building block in organic synthesis, particularly in the development of kinase inhibitors and antiviral agents. Its bromine moiety enables efficient participation in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. Researchers utilize this compound to modify pyrimidine cores in drug candidates, enhancing bioavailability and target specificity. It is also employed in agrochemical research for designing novel herbicides and fungicides.

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