Description

Fluoro-N,N,N’,N’-tetramethylformamidinium Hexafluorophosphate (CAS: 164298-23-1) is a high-purity organic salt widely used as a coupling reagent in peptide synthesis and other organic transformations. With the molecular formula C₅H₁₂F₇N₂P, this compound is characterized by its excellent stability and reactivity under mild conditions, making it ideal for sensitive chemical processes. It is supplied as a white to off-white crystalline powder with ≥98% purity, ensuring consistent performance in research and industrial applications. Suitable for use in anhydrous environments, this reagent is stored under inert conditions to maintain its integrity. Each batch undergoes rigorous QC testing, including HPLC and NMR analysis, to guarantee compliance with industry standards.

Properties

• CAS Number: 164298-23-1
• Complexity: 153
• IUPAC Name: [dimethylamino(fluoro)methylene]-dimethyl-ammonium;hexafluorophosphate
• InChI: InChI=1S/C5H12FN2.F6P/c1-7(2)5(6)8(3)4;1-7(2,3,4,5)6/h1-4H3;/q+1;-1
• InChI Key: ZAVXOOLKAGPJPI-UHFFFAOYSA-N
• Exact Mass: 264.06263252
• Molecular Formula: C5H12F7N2P
• Molecular Weight: 264.12
• SMILES: CN(C)C(=[N+](C)C)F.F[P-](F)(F)(F)(F)F
• Topological: 6.3
• Monoisotopic Mass: 264.06263252
• Synonyms: Fluoro-N,N,N’,N’-tetramethylformamidinium hexafluorophosphate, Methanaminium, N-[(dimethylamino)fluoromethylene]-N-methyl-, hexafluorophosphate(1-) (1:1), Methanaminium, N-((dimethylamino)fluoromethylene)-N-methyl-, hexafluorophosphate(1-) (1:1), 627-657-1, 164298-23-1, TFFH, N-((Dimethylamino)fluoromethylene)-N-methylmethanaminium hexafluorophosphate(V), MFCD02684443, [dimethylamino(fluoro)methylidene]-dimethylazanium;hexafluorophosphate, TETRAMETHYLFLUOROFORMAMIDINIUM HEXAFLUOROPHOSPHATE, N,N,N’,N’-Tetramethylfluoroformamidinium hexafluorophosphate, Tetramethylfluoroformamidinium (hexafluorophosphate), ZAVXOOLKAGPJPI-UHFFFAOYSA-N, Tetramethylfluoroformamidiniun hexafluorophosphate, SCHEMBL789737, SBB102764, TFFH, Fluoro-N,N,N’,N’-tetramethylformamidinium hexafluorophosphate, AKOS015909557, CS-W012450, FT35332, HY-W011734, AC-24884, AS-15204, Fluoro-N,N,N inverted exclamation marka,N inverted exclamation marka-tetramethylformamidinium hexafluorophosphate, PD200221, SY019066, F0726, EN300-310977, O11984, Tetramethyl fluoroformamidium hexafluorophosphate, tetramethyl fluoroformamidinium hexafluorophosphate, 1,1,3,3-tetramethylfluoroformamidinium hexafluorophosphate, fluoro-N,N,N’,N’ tetramethylformamidinium hexafluorophosphate, Fluoro-N,N,N’,N’-tetramethylformamidinium hexafluorophosphate, N,N,N’,N’-tetramethylfluoroformamidinium hexafluoro-phosphate, Tffh; fluoro-N,N,N,N-etramethylformamidinium hexafluorophosphate, [dimethylamino(fluoro)methylene]-dimethyl-ammonium;hexafluorophosphate, [(dimethylamino)(fluoro)methylidene]dimethylazanium; hexafluoro-lambda5-phosphanuide, N-((dimethylamino)fluoromethylene)-N-methylmethanaminium hexafluorophosphate (V), N-((Dimethylamino)fluoromethylene)-N-methylmethanaminiumhexafluorophosphate(V), Fluoro-N,N,N inverted exclamation mark ,N inverted exclamation mark -tetramethylformamidinium Hexafluorophosphate

Fluoro-N,N,N’,N’-tetramethylformamidinium Hexafluorophosphate (TFFH) is primarily employed as a peptide coupling agent, facilitating amide bond formation with minimal racemization. It is particularly useful in solid-phase peptide synthesis (SPPS) and solution-phase reactions due to its mild activation properties. Additionally, TFFH serves as a versatile reagent in the synthesis of heterocycles and other complex organic molecules. Its compatibility with sensitive functional groups makes it a preferred choice for advanced pharmaceutical research. Researchers also utilize TFFH in combinatorial chemistry for high-throughput screening applications.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (95.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (95.7%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.