Description

5-Methylpicolinonitrile (CAS No. 1620-77-5) is a high-purity organic compound with the molecular formula C₇H₆N₂ and the IUPAC name 5-methylpyridine-2-carbonitrile. This specialized nitrile derivative is a valuable building block in pharmaceutical and agrochemical synthesis, offering a reactive cyano group adjacent to a methyl-substituted pyridine ring. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Suitable for use in cross-coupling reactions, heterocyclic synthesis, and as a precursor for bioactive molecules. Packaged under inert gas in amber glass vials with PTFE-lined caps to ensure stability. Technical data sheet includes ¹H/¹³C NMR spectra, GC-MS analysis, and residual solvent reports. Store in a cool, dry place at 2-8°C under inert atmosphere.

Properties

• CAS Number: 1620-77-5
• Complexity: 133
• IUPAC Name: 5-methylpyridine-2-carbonitrile
• InChI: InChI=1S/C7H6N2/c1-6-2-3-7(4-8)9-5-6/h2-3,5H,1H3
• InChI Key: LIEQVZZZYLHNRH-UHFFFAOYSA-N
• Exact Mass: 118.053098200
• Molecular Formula: C7H6N2
• Molecular Weight: 118.14
• SMILES: CC1=CN=C(C=C1)C#N
• Topological: 36.7
• Monoisotopic Mass: 118.053098200
• Synonyms: 2-cyano-5-methylpyridine, 5-methylpicolinonitrile, 5-Methylpyridine-2-carbonitrile, 2-Pyridinecarbonitrile, 5-methyl-, 5-Methyl-2-pyridinecarbonitrile, 5-methyl-2-cyanopyridine, BTZ4BG8Z8D, DTXSID20167285, DTXCID5089776, 1620-77-5, 5-Methyl-pyridine-2-carbonitrile, MFCD06200830, 6-Cyano-3-picoline, 2-Cyano-5-methylpyridine (2-Cyano-5-picoline), EINECS 216-589-4, 5-methyl picolinonitrile, UNII-BTZ4BG8Z8D, 5-methyl-2-cyano-pyridine, SCHEMBL81947, SCHEMBL130125, SCHEMBL4754128, 5-methyl pyridine-2-carbonitrile, SBB055740, AKOS005257581, AS-5423, CS-W003262, AC-24938, SY009853, DB-012279, C2706, NS00025294, EN300-115964

Application

5-Methylpicolinonitrile serves as a key intermediate in the synthesis of novel pyridine-containing pharmaceuticals, particularly in the development of kinase inhibitors and CNS-active compounds. The compound’s reactive nitrile group enables facile conversion to amidines, tetrazoles, and other nitrogen-rich heterocycles important in medicinal chemistry. Researchers utilize this building block in palladium-catalyzed cross-coupling reactions to construct complex bioactive molecules. In material science, it finds application as a precursor for liquid crystal intermediates and coordination complexes with transition metals.

Safety and Hazards

GHS Hazard Statements

• H301 (20%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302+H312+H332 (40%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (60%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (60%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (60%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (20%)
• Acute Tox. 4 (60%)
• Acute Tox. 4 (60%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (60%)
• STOT SE 3 (80%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.