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Atomfair 5-Methylpicolinonitrile C7H6N2 CAS 1620-77-5

5-Methylpicolinonitrile (CAS No. 1620-77-5) is a high-purity organic compound with the molecular formula C7H6N2and the IUPAC name 5-methylpyridine-2-carbonitrile . This specialized nitrile derivative is a valuable building block in pharmaceutical and agrochemical synthesis, offering a reactive cyano group adjacent to a methyl-substituted pyridine ring. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Suitable for use in cross-coupling reactions, heterocyclic synthesis, and as a precursor for bioactive molecules. Packaged under inert gas in amber glass vials with PTFE-lined caps to ensure stability. Technical data sheet…

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Description

5-Methylpicolinonitrile (CAS No. 1620-77-5) is a high-purity organic compound with the molecular formula C7H6N2 and the IUPAC name 5-methylpyridine-2-carbonitrile. This specialized nitrile derivative is a valuable building block in pharmaceutical and agrochemical synthesis, offering a reactive cyano group adjacent to a methyl-substituted pyridine ring. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Suitable for use in cross-coupling reactions, heterocyclic synthesis, and as a precursor for bioactive molecules. Packaged under inert gas in amber glass vials with PTFE-lined caps to ensure stability. Technical data sheet includes 1H/13C NMR spectra, GC-MS analysis, and residual solvent reports. Store in a cool, dry place at 2-8°C under inert atmosphere.

Properties

  • CAS Number: 1620-77-5
  • Complexity: 133
  • IUPAC Name: 5-methylpyridine-2-carbonitrile
  • InChI: InChI=1S/C7H6N2/c1-6-2-3-7(4-8)9-5-6/h2-3,5H,1H3
  • InChI Key: LIEQVZZZYLHNRH-UHFFFAOYSA-N
  • Exact Mass: 118.053098200
  • Molecular Formula: C7H6N2
  • Molecular Weight: 118.14
  • SMILES: CC1=CN=C(C=C1)C#N
  • Topological: 36.7
  • Monoisotopic Mass: 118.053098200
  • Synonyms: 2-cyano-5-methylpyridine, 5-methylpicolinonitrile, 5-Methylpyridine-2-carbonitrile, 2-Pyridinecarbonitrile, 5-methyl-, 5-Methyl-2-pyridinecarbonitrile, 5-methyl-2-cyanopyridine, BTZ4BG8Z8D, DTXSID20167285, DTXCID5089776, 1620-77-5, 5-Methyl-pyridine-2-carbonitrile, MFCD06200830, 6-Cyano-3-picoline, 2-Cyano-5-methylpyridine (2-Cyano-5-picoline), EINECS 216-589-4, 5-methyl picolinonitrile, UNII-BTZ4BG8Z8D, 5-methyl-2-cyano-pyridine, SCHEMBL81947, SCHEMBL130125, SCHEMBL4754128, 5-methyl pyridine-2-carbonitrile, SBB055740, AKOS005257581, AS-5423, CS-W003262, AC-24938, SY009853, DB-012279, C2706, NS00025294, EN300-115964

Application

5-Methylpicolinonitrile serves as a key intermediate in the synthesis of novel pyridine-containing pharmaceuticals, particularly in the development of kinase inhibitors and CNS-active compounds. The compound’s reactive nitrile group enables facile conversion to amidines, tetrazoles, and other nitrogen-rich heterocycles important in medicinal chemistry. Researchers utilize this building block in palladium-catalyzed cross-coupling reactions to construct complex bioactive molecules. In material science, it finds application as a precursor for liquid crystal intermediates and coordination complexes with transition metals.

Safety and Hazards

GHS Hazard Statements

  • H301 (20%): Toxic if swallowed [Danger Acute toxicity, oral]
  • H302+H312+H332 (40%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
  • H302 (60%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (60%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (60%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 3 (20%)
  • Acute Tox. 4 (60%)
  • Acute Tox. 4 (60%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • Acute Tox. 4 (60%)
  • STOT SE 3 (80%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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