Description

2-Fluoropyridin-3-amine (CAS No. 1597-33-7) is a high-purity fluorinated pyridine derivative with the molecular formula C₅H₅FN₂. This compound, also known as 3-Amino-2-fluoropyridine, is a valuable building block in pharmaceutical and agrochemical research due to its unique structural properties. The presence of both fluorine and amine groups on the pyridine ring enhances its reactivity, making it an ideal intermediate for nucleophilic substitution reactions, cross-coupling reactions, and heterocyclic synthesis. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied as a fine white to off-white crystalline powder. Suitable for use in medicinal chemistry, material science, and as a ligand in catalysis. Packaged under inert gas to ensure stability and long shelf life.

Properties

• CAS Number: 1597-33-7
• Complexity: 76.8
• IUPAC Name: 2-fluoropyridin-3-amine
• InChI: InChI=1S/C5H5FN2/c6-5-4(7)2-1-3-8-5/h1-3H,7H2
• InChI Key: QVDACIZNNNFTBO-UHFFFAOYSA-N
• Exact Mass: 112.04367633
• Molecular Formula: C5H5FN2
• Molecular Weight: 112.10
• SMILES: C1=CC(=C(N=C1)F)N
• Topological: 38.9
• Monoisotopic Mass: 112.04367633
• Synonyms: 2-fluoropyridin-3-amine, 663-268-3, 3-Amino-2-fluoropyridine, 1597-33-7, 3-PYRIDINAMINE, 2-FLUORO-, 2-fluoro-pyridin-3-ylamine, MFCD03095248, 3-AMINO-2-FLUORO-PYRIDINE, 2-fluoro-3-pyridylamine, 2-FLUORO-3-PYRIDINAMINE, 2-Fluoro-3-pyridinylamine, SCHEMBL998033, SCHEMBL2067016, SCHEMBL2069384, SCHEMBL6544438, DTXSID80376477, 3-Amino-2-fluoropyridine, 95%, QVDACIZNNNFTBO-UHFFFAOYSA-N, BBL103654, SBB069766, STL557464, AKOS005064023, AC-2366, CS-W008831, PS-9247, SB33986, SY030938, DB-022195, A2650, EN300-95260

Application

2-Fluoropyridin-3-amine is widely used as a key intermediate in the synthesis of biologically active compounds, including pharmaceuticals and agrochemicals. Its fluorine and amine functional groups make it a versatile precursor for the development of kinase inhibitors, antiviral agents, and herbicide candidates. Researchers utilize this compound in cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig) to construct complex heterocyclic scaffolds. It also serves as a ligand in transition metal catalysis for asymmetric synthesis. Suitable for high-throughput screening and combinatorial chemistry applications.

Safety and Hazards

GHS Hazard Statements

• H302 (95.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501

Hazard Classes and Categories

• Acute Tox. 4 (95.1%)
• Eye Irrit. 2A (100%)

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