Description

tert-butyl N-(2-methoxyphenyl)carbamate (CAS No. 154150-18-2) is a high-purity carbamate derivative with the molecular formula C₁₂H₁₇NO₃. This compound is widely utilized in organic synthesis and pharmaceutical research due to its role as a protected aniline intermediate. The tert-butyl carbamate (BOC) group provides excellent stability under basic and nucleophilic conditions, making it ideal for multi-step synthetic applications. With a molecular weight of 223.27 g/mol, this white to off-white crystalline solid is characterized by its high solubility in common organic solvents such as dichloromethane, ethyl acetate, and dimethylformamide. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied in sealed containers under inert gas to maintain integrity. Suitable for use in peptide coupling, heterocycle synthesis, and as a precursor in medicinal chemistry.

Properties

• CAS Number: 154150-18-2
• Complexity: 235
• IUPAC Name: tert-butyl N-(2-methoxyphenyl)carbamate
• InChI: InChI=1S/C12H17NO3/c1-12(2,3)16-11(14)13-9-7-5-6-8-10(9)15-4/h5-8H,1-4H3,(H,13,14)
• InChI Key: DHSWMVURURVRDB-UHFFFAOYSA-N
• Exact Mass: 223.12084340
• Molecular Formula: C12H17NO3
• Molecular Weight: 223.27
• SMILES: CC(C)(C)OC(=O)NC1=CC=CC=C1OC
• Topological: 47.6
• Monoisotopic Mass: 223.12084340
• Synonyms: tert-butyl N-(2-methoxyphenyl)carbamate, 939-170-4, 154150-18-2, tert-Butyl (2-methoxyphenyl)carbamate, N-BOC-2-METHOXYANILINE, Tert-butyl 2-methoxyphenylcarbamate, (2-METHOXYPHENYL)-CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER, MFCD07127728, 2-Methoxyaniline, N-BOC protected, tert-Butyl(2-methoxyphenyl)carbamate, SCHEMBL729221, SCHEMBL3337602, N-Boc-2-methoxyaniline, 97%, SCHEMBL27685678, DTXSID90406855, DHSWMVURURVRDB-UHFFFAOYSA-N, EGA15018, AKOS003581112, N-(t-butoxycarbonyl)-2-methoxyaniline, AB30560, SS-4421, tert-butyl-N-(2-methoxyphenyl)carbamate, AC-14184, SY158196, DB-064022, CS-0154411, EN300-160612, F14355, Z1258794272

Application

tert-butyl N-(2-methoxyphenyl)carbamate serves as a key intermediate in the synthesis of pharmaceuticals, particularly in the protection of amine functionalities during complex reactions. It is commonly employed in the preparation of active pharmaceutical ingredients (APIs) and agrochemicals. Researchers also utilize this compound in the development of novel heterocyclic compounds and as a building block in combinatorial chemistry. Its stability under basic conditions makes it valuable for orthogonal deprotection strategies in multi-step syntheses.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.