Description

2-Fluoro-6-(trifluoromethyl)benzyl alcohol (CAS No. 152211-15-9) is a high-purity fluorinated benzyl alcohol derivative with the molecular formula C₈H₆F₄O. This compound, also known by its IUPAC name [2-fluoro-6-(trifluoromethyl)phenyl]methanol, is a versatile building block for pharmaceutical, agrochemical, and materials science research. Its unique structure, featuring both fluorine and trifluoromethyl substituents, enhances lipophilicity and metabolic stability, making it valuable in medicinal chemistry. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied in sealed containers under inert gas to maintain stability. Suitable for nucleophilic substitutions, esterifications, and as a precursor for chiral ligands.

Properties

• CAS Number: 152211-15-9
• Complexity: 168
• IUPAC Name: [2-fluoro-6-(trifluoromethyl)phenyl]methanol
• InChI: InChI=1S/C8H6F4O/c9-7-3-1-2-6(5(7)4-13)8(10,11)12/h1-3,13H,4H2
• InChI Key: TZUCYZIRXZYZOP-UHFFFAOYSA-N
• Exact Mass: 194.03547746
• Molecular Formula: C8H6F4O
• Molecular Weight: 194.13
• SMILES: C1=CC(=C(C(=C1)F)CO)C(F)(F)F
• Topological: 20.2
• Monoisotopic Mass: 194.03547746
• Synonyms: 2-Fluoro-6-(trifluoromethyl)benzyl alcohol, 152211-15-9, DTXSID60333886, DTXCID70284976, 621-952-9, tzucyzirxzyzop-uhfffaoysa-n, (2-Fluoro-6-(trifluoromethyl)phenyl)methanol, [2-Fluoro-6-(trifluoromethyl)phenyl]methanol, MFCD00061168, [6-fluoro-2-(trifluoromethyl)phenyl]methan-1-ol, SCHEMBL2776951, CK2485, SBB091698, AKOS005063787, PS-8305, SY032139, DB-043132, CS-0077932, ST50407102, [2-Fluoro-6-(trifluoromethyl)phenyl]methanol #, 2-Fluoro-6-(trifluoromethyl)benzyl alcohol, 99%

Application

2-Fluoro-6-(trifluoromethyl)benzyl alcohol is widely used as an intermediate in the synthesis of bioactive molecules, particularly in the development of CNS-targeting pharmaceuticals due to its blood-brain barrier permeability. It serves as a key precursor for fluorinated liquid crystals and corrosion inhibitors in specialty coatings. Researchers also employ this compound in Suzuki-Miyaura cross-coupling reactions to create advanced materials with tailored electronic properties.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.7%)

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