Description

Methyl 2-(3-aminophenyl)acetate hydrochloride (CAS No. 150319-83-8) is a high-purity organic compound with the molecular formula C₉H₁₂ClNO₂. This hydrochloride salt derivative of methyl 3-aminophenylacetate is a valuable intermediate in pharmaceutical and biochemical research. The compound features a benzene ring substituted with an amino group at the meta position and an ester-functionalized acetic acid side chain, protonated as a hydrochloride salt for enhanced stability.

With a molecular weight of 201.65 g/mol, this white to off-white crystalline powder is ideal for synthetic applications requiring precise control over aromatic amine reactivity. The hydrochloride form improves solubility in polar solvents while maintaining the reactivity of the aromatic amine group. Our product is rigorously tested to ensure ≥95% purity by HPLC, with detailed analytical data (NMR, MS) available upon request.

Packaged under inert atmosphere in amber glass vials to prevent degradation, this chemical is suitable for use as:

• Key intermediate in active pharmaceutical ingredient (API) synthesis
• Building block for heterocyclic compound preparation
• Precursor for functional materials research

Properties

• CAS Number: 150319-83-8
• Complexity: 159
• IUPAC Name: methyl 2-(3-aminophenyl)acetate;hydrochloride
• InChI: InChI=1S/C9H11NO2.ClH/c1-12-9(11)6-7-3-2-4-8(10)5-7;/h2-5H,6,10H2,1H3;1H
• InChI Key: OOGVJPZOIXNNHQ-UHFFFAOYSA-N
• Exact Mass: 201.0556563
• Molecular Formula: C9H12ClNO2
• Molecular Weight: 201.65
• SMILES: COC(=O)CC1=CC(=CC=C1)N.Cl
• Topological: 52.3
• Monoisotopic Mass: 201.0556563
• Synonyms: Methyl 2-(3-aminophenyl)acetate hydrochloride, 696-570-9, 150319-83-8, Methyl 3-aminophenylacetate hydrochloride, 3-Aminophenylacetic acid methyl ester HCl, MFCD11501071, Methyl 3-aminophenylacetate, HCl, 3-Aminophenylacetic acid methyl ester hydrochloride, methyl 2-(3-aminophenyl)acetate;hydrochloride, Benzeneacetic acid, 3-amino-, methyl ester, hydrochloride (1:1), METHYL 2-(3-AMINOPHENYL)ACETATE HCL, 3-amino phenylacetic acid methylester hydrochloride, Methyl (3-aminophenyl)acetate hydrochloride, SCHEMBL3949455, SCHEMBL6984256, DTXSID90657325, OOGVJPZOIXNNHQ-UHFFFAOYSA-N, AKOS008152559, FM65833, PS-8193, SB77940, Methyl(3-aminophenyl)acetate hydrochloride, SY024502, DB-356852, Methyl2-(3-aminophenyl)acetatehydrochloride, CS-0208214, EN300-83024, Methyl (3-aminophenyl)acetate–hydrogen chloride (1/1), Z1250132316

Application

Methyl 2-(3-aminophenyl)acetate hydrochloride serves as a versatile intermediate in medicinal chemistry, particularly in the synthesis of non-steroidal anti-inflammatory drug candidates. The compound’s aromatic amine functionality allows for diverse derivatization through diazotization, acylation, or coupling reactions. Researchers utilize this material in developing novel benzodiazepine analogs and other CNS-active compounds. The ester group provides a handle for further transformation to carboxylic acid derivatives or amide formation.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.