Description

2-Chloro-3-fluoro-4-iodopyridine (CAS: 148639-07-0) is a high-purity halogenated pyridine derivative designed for advanced synthetic and pharmaceutical research applications. This compound, with the molecular formula C₅H₂ClFIN, serves as a versatile building block in organofluorine and organoiodine chemistry. Its unique substitution pattern enables selective functionalization, making it invaluable for the development of agrochemicals, pharmaceuticals, and specialty materials. Each batch undergoes rigorous QC testing (HPLC, NMR) to ensure ≥98% purity, meeting the stringent requirements of medicinal chemistry and cross-coupling reactions. Packaged under inert gas to enhance stability, this product is ideal for researchers seeking reliable intermediates for Suzuki-Miyaura, Negishi, or Stille couplings.

Properties

• CAS Number: 148639-07-0
• Complexity: 103
• IUPAC Name: 2-chloro-3-fluoro-4-iodo-pyridine
• InChI: InChI=1S/C5H2ClFIN/c6-5-4(7)3(8)1-2-9-5/h1-2H
• InChI Key: GONULLRFSHKLBS-UHFFFAOYSA-N
• Exact Mass: 256.89045
• Molecular Formula: C5H2ClFIN
• Molecular Weight: 257.43
• SMILES: C1=CN=C(C(=C1I)F)Cl
• Topological: 12.9
• Monoisotopic Mass: 256.89045
• Synonyms: 2-Chloro-3-fluoro-4-iodopyridine, 148639-07-0, DTXSID40453955, DTXCID30404774, 821-637-8, Pyridine, 2-chloro-3-fluoro-4-iodo-, MFCD04972389, 2-chloro-3-fluoro-4-iodo-pyridine, SCHEMBL792915, GONULLRFSHKLBS-UHFFFAOYSA-N, BBL104034, STL557848, AKOS005259352, DS-1498, AC-33397, SY022337, DB-024977, C3375, CS-0030551, EN300-1708497

Application

2-Chloro-3-fluoro-4-iodopyridine is extensively used as a key intermediate in pharmaceutical synthesis, particularly for constructing fluorinated and iodinated drug scaffolds. Its reactivity facilitates palladium-catalyzed cross-coupling reactions to create complex heterocycles in kinase inhibitor development. The compound also finds utility in material science for designing liquid crystals and OLED precursors. Researchers leverage its halogen diversity for sequential functionalization in medicinal chemistry programs.

Safety and Hazards

GHS Hazard Statements

• H302+H312+H332 (93.3%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (96.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (96.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (96.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (96.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (96.7%)
• Acute Tox. 4 (96.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (96.7%)
• STOT SE 3 (96.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.