Description

3-Chloro-2-fluoropyridine (CAS No. 1480-64-4) is a high-purity halogenated pyridine derivative widely used in pharmaceutical, agrochemical, and materials science research. This compound, with the molecular formula C₅H₃ClFN, serves as a versatile building block for synthesizing complex heterocyclic structures due to its reactive chloro and fluoro substituents. Its precise molecular weight of 131.54 g/mol and well-characterized properties make it ideal for nucleophilic substitution reactions, cross-coupling reactions, and as a precursor in medicinal chemistry. Available in >98% purity (GC), this product is rigorously tested for consistency and stability, ensuring reliable performance in demanding applications. Packaged under inert gas to prevent degradation, it is supplied in amber glass vials or bulk quantities with detailed technical documentation, including NMR, HPLC, and MSDS data.

Properties

• CAS Number: 1480-64-4
• Complexity: 78.8
• IUPAC Name: 3-chloro-2-fluoro-pyridine
• InChI: InChI=1S/C5H3ClFN/c6-4-2-1-3-8-5(4)7/h1-3H
• InChI Key: IHGMHTQDGNVKTA-UHFFFAOYSA-N
• Exact Mass: 130.9938050
• Molecular Formula: C5H3ClFN
• Molecular Weight: 131.53
• SMILES: C1=CC(=C(N=C1)F)Cl
• Topological: 12.9
• Monoisotopic Mass: 130.9938050
• Synonyms: 3-Chloro-2-fluoropyridine, 1480-64-4, DTXSID00376479, DTXCID00327507, 674-761-8, 3-chloro-2-fluoro-pyridine, 2-fluoro-3-chloropyridine, MFCD04114144, Pyridine, 3-chloro-2-fluoro-, chlorofluoropyridine, SCHEMBL230359, SCHEMBL363908, SCHEMBL7760430, SCHEMBL18938734, IHGMHTQDGNVKTA-UHFFFAOYSA-N, BCP22194, BBL100887, SBB085790, STL554681, AKOS005064127, CS-W003157, PS-9139, AC-24487, SY024689, DB-028423, A3240, C2515, EN300-101596

3-Chloro-2-fluoropyridine is primarily employed as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. Its dual halogen functionality enables selective modifications, making it valuable for constructing pyridine-based scaffolds in drug discovery. Researchers also utilize it in palladium-catalyzed cross-coupling reactions to develop novel materials and ligands. In agrochemistry, it contributes to the creation of advanced crop protection agents with enhanced efficacy.

Safety and Hazards

GHS Hazard Statements

• H226 (88.9%): Flammable liquid and vapor [Warning Flammable liquids]
• H302+H312+H332 (11.1%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (77.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (77.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (77.8%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (22.2%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (22.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (77.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (11.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (88.9%)
• Acute Tox. 4 (77.8%)
• Acute Tox. 4 (77.8%)
• Skin Corr. 1B (77.8%)
• Skin Irrit. 2 (22.2%)
• Eye Irrit. 2 (22.2%)
• Acute Tox. 4 (77.8%)
• STOT SE 3 (11.1%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.