Description

3-Fluoro-2-methylbenzaldehyde (CAS No. 147624-13-3) is a high-purity aromatic aldehyde with the molecular formula C₈H₇FO. This compound features a fluorine substituent at the 3-position and a methyl group at the 2-position of the benzaldehyde ring, offering unique reactivity for electrophilic aromatic substitution and nucleophilic addition reactions. Ideal for pharmaceutical intermediates, agrochemical synthesis, and material science applications, this reagent is rigorously tested for purity (typically ≥95% by GC or HPLC) and consistency. Available in various quantities, it is supplied in sealed containers under inert gas to ensure stability and longevity. Suitable for researchers requiring precise fluorinated building blocks in organic synthesis.

Properties

• CAS Number: 147624-13-3
• Complexity: 124
• IUPAC Name: 3-fluoro-2-methyl-benzaldehyde
• InChI: InChI=1S/C8H7FO/c1-6-7(5-10)3-2-4-8(6)9/h2-5H,1H3
• InChI Key: HSUCYMJBFHBMTB-UHFFFAOYSA-N
• Exact Mass: 138.048093005
• Molecular Formula: C8H7FO
• Molecular Weight: 138.14
• SMILES: CC1=C(C=CC=C1F)C=O
• Topological: 17.1
• Monoisotopic Mass: 138.048093005
• Synonyms: 3-Fluoro-2-methylbenzaldehyde, 147624-13-3, DTXSID10381337, DTXCID90332362, 628-146-6, BENZALDEHYDE, 3-FLUORO-2-METHYL-, 2-methyl-3-fluorobenzaldehyde, 3-Fluoro-2-Methyl-Benzaldehyde, MFCD00075256, SCHEMBL97028, SCHEMBL97029, HSUCYMJBFHBMTB-UHFFFAOYSA-N, BCP24589, SBB052190, 3-Fluoro-2-methylbenzaldehyde, 98%, AKOS015852973, 3-Fluoro-2-methylbenzaldehyde – 80%, AC-2832, CS-W002321, FF70830, PS-9088, SY003067, F1197, EN300-201565, Z1255402882, InChI=1/C8H7FO/c1-6-7(5-10)3-2-4-8(6)9/h2-5H,1H

Application

3-Fluoro-2-methylbenzaldehyde serves as a versatile intermediate in the synthesis of fluorinated pharmaceuticals, agrochemicals, and specialty materials. Its electron-withdrawing fluorine and sterically accessible aldehyde group facilitate reactions such as condensations, Grignard additions, and reductive aminations. Commonly used in the development of bioactive molecules, it is particularly valuable in constructing heterocyclic scaffolds for drug discovery. Researchers also employ it in ligand design for catalysis and as a precursor for fluorinated polymers.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

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