Description

Methyl (2R)-2-fluoropropanoate (CAS No. 146805-74-5) is a high-purity chiral fluorinated ester with the molecular formula C₄H₇FO₂. This compound is a valuable building block in organic synthesis and pharmaceutical research, particularly for the introduction of fluorine atoms into target molecules. Its (R)-enantiomeric form ensures stereochemical precision, making it ideal for asymmetric synthesis and the development of bioactive compounds. The product is rigorously tested for purity and stability, ensuring reliable performance in sensitive applications. Packaged under inert conditions to prevent degradation, it is suitable for use in medicinal chemistry, agrochemical research, and material science.

Properties

• CAS Number: 146805-74-5
• Complexity: 72.1
• IUPAC Name: methyl (2R)-2-fluoropropanoate
• InChI: InChI=1S/C4H7FO2/c1-3(5)4(6)7-2/h3H,1-2H3/t3-/m1/s1
• InChI Key: MHAIQPNJLRLFLO-GSVOUGTGSA-N
• Exact Mass: 106.04300762
• Molecular Formula: C4H7FO2
• Molecular Weight: 106.10
• SMILES: C[C@H](C(=O)OC)F
• Topological: 26.3
• Monoisotopic Mass: 106.04300762
• Synonyms: methyl (2r)-2-fluoropropanoate, 478-990-2, (r)-methyl 2-fluoropropionate, 146805-74-5, methyl (r)-2-fluoropropionate, (R)-2-Fluoro-propionic acid methyl ester, MFCD08457465, SCHEMBL98578, Methyl(R)-2-fluoropropionate, (r)-methyl 2-fluoropropanoate, Methyl (R)-2-fluoropropanoate, DTXSID90447925, MHAIQPNJLRLFLO-GSVOUGTGSA-N, AKOS006346049, DB-351727, CS-0446921, NS00006392

Application

Methyl (2R)-2-fluoropropanoate is widely used as a chiral synthon in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its stereospecificity makes it valuable for constructing enantiomerically pure compounds with enhanced biological activity. Researchers utilize this ester in nucleophilic fluorination reactions and as a precursor for fluorinated amino acids. It is also employed in the development of PET radiotracers and other diagnostic agents.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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