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Atomfair 1-Ethoxy-2,3-difluoro-4-iodobenzene C8H7F2IO CAS 144292-42-2

1-Ethoxy-2,3-difluoro-4-iodobenzene (CAS No. 144292-42-2) is a high-purity fluorinated aromatic compound with the molecular formula C8H7F2IO . This specialized chemical is designed for advanced research and industrial applications, featuring an ethoxy group and iodine substitution on a difluorobenzene backbone. Its unique structure makes it a valuable intermediate in organic synthesis, particularly in pharmaceutical development, agrochemical research, and materials science. The compound is supplied with comprehensive analytical data including1H NMR,13C NMR, and mass spectrometry verification to ensure quality and consistency. Available in various quantities with strict purity standards (typically ≥95% by GC analysis), it is packaged under inert atmosphere to maintain stability.…

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Description

1-Ethoxy-2,3-difluoro-4-iodobenzene (CAS No. 144292-42-2) is a high-purity fluorinated aromatic compound with the molecular formula C8H7F2IO. This specialized chemical is designed for advanced research and industrial applications, featuring an ethoxy group and iodine substitution on a difluorobenzene backbone. Its unique structure makes it a valuable intermediate in organic synthesis, particularly in pharmaceutical development, agrochemical research, and materials science. The compound is supplied with comprehensive analytical data including 1H NMR, 13C NMR, and mass spectrometry verification to ensure quality and consistency. Available in various quantities with strict purity standards (typically ≥95% by GC analysis), it is packaged under inert atmosphere to maintain stability. Suitable for use in cross-coupling reactions, nucleophilic substitutions, and as a building block for more complex fluorinated compounds.

Properties

  • CAS Number: 144292-42-2
  • Complexity: 145
  • IUPAC Name: 1-ethoxy-2,3-difluoro-4-iodo-benzene
  • InChI: InChI=1S/C8H7F2IO/c1-2-12-6-4-3-5(11)7(9)8(6)10/h3-4H,2H2,1H3
  • InChI Key: WZQBGHWYRCIGDB-UHFFFAOYSA-N
  • Exact Mass: 283.95097
  • Molecular Formula: C8H7F2IO
  • Molecular Weight: 284.04
  • SMILES: CCOC1=C(C(=C(C=C1)I)F)F
  • Topological: 9.2
  • Monoisotopic Mass: 283.95097
  • Synonyms: 1-ETHOXY-2,3-DIFLUORO-4-IODOBENZENE, 144292-42-2, DTXSID20621438, DTXCID60572192, 103-279-8, Benzene, 1-ethoxy-2,3-difluoro-4-iodo-, MFCD16619252, 4-iodo-2,3-difluorophenetole, SCHEMBL2821417, 4-ethoxy-2,3-difluoroiodobenzene, DB-002374, CS-0190739, E91200, EN300-307028

Application

1-Ethoxy-2,3-difluoro-4-iodobenzene serves as a versatile intermediate in pharmaceutical synthesis, particularly for introducing fluorine-containing aromatic moieties into drug candidates. Its reactive iodine position enables participation in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, or Sonogashira couplings) for creating biaryl structures. The compound finds use in material science for developing liquid crystals and fluorinated polymers with enhanced thermal stability. Researchers also employ it as a precursor for synthesizing fluorinated ligands in catalytic systems.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • Acute Tox. 4 (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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