Description

1,2-Dichloro-4-fluorobenzene (CAS No. 1435-49-0) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃Cl₂F. This versatile intermediate is widely used in organic synthesis, pharmaceuticals, and agrochemical research. Its unique structure, featuring two chlorine atoms and one fluorine atom on a benzene ring, makes it an excellent building block for further functionalization. Available in >98% purity (GC), this compound is supplied in sealed containers under inert gas to ensure stability and longevity. Ideal for Suzuki couplings, nucleophilic substitutions, and other advanced synthetic applications. Store in a cool, dry place away from light and moisture.

Properties

• CAS Number: 1435-49-0
• Complexity: 97.1
• IUPAC Name: 1,2-dichloro-4-fluoro-benzene
• InChI: InChI=1S/C6H3Cl2F/c7-5-2-1-4(9)3-6(5)8/h1-3H
• InChI Key: QSDKXMVGRLVIQV-UHFFFAOYSA-N
• Exact Mass: 163.9595836
• Molecular Formula: C6H3Cl2F
• Molecular Weight: 164.99
• SMILES: C1=CC(=C(C=C1F)Cl)Cl
• Monoisotopic Mass: 163.9595836
• Synonyms: 1,2-Dichloro-4-fluorobenzene, 1435-49-0, 3,4-Dichlorofluorobenzene, EINECS 215-858-3, DTXSID90162444, NSC 82300, DTXCID0084935, 215-858-3, qsdkxmvgrlviqv-uhfffaoysa-n, Benzene, 1,2-dichloro-4-fluoro-, MFCD00018119, 3,4-dichloro-1-fluorobenzene, NSC-82300, 1,2-dichloro-4-fluoro-benzene, NSC82300, 3,4 dichlorofluorobenzene, SCHEMBL262186, SCHEMBL442153, SCHEMBL529658, SCHEMBL976785, GV59588LD8, SBB087867, AKOS006222092, CS-W017895, AC-26083, AS-59290, DB-021865, D3570, NS00044678, ST50405266, EN300-123949

Application

1,2-Dichloro-4-fluorobenzene serves as a key intermediate in pharmaceutical synthesis, particularly for active pharmaceutical ingredients (APIs) with halogenated aromatic moieties. It is also employed in agrochemical research for developing novel pesticides and herbicides. Researchers utilize this compound in material science for creating specialty polymers and liquid crystals.

Safety and Hazards

GHS Hazard Statements

• H302 (86.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (86.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.