Description

2,4-Dichloro-1-fluorobenzene (CAS No. 1435-48-9) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃Cl₂F. This colorless to pale-yellow liquid is a versatile intermediate in organic synthesis, offering excellent reactivity for nucleophilic substitution and cross-coupling reactions. With a boiling point of approximately 178-180°C and density of 1.45 g/cm³, it is particularly valuable for pharmaceutical, agrochemical, and material science applications. Our product is rigorously tested by HPLC and GC to ensure >98% purity, packaged under nitrogen to prevent degradation. Available in quantities from grams to bulk kilograms with customizable packaging options.

Key Features:

• High reactivity at both chloro and fluoro positions for selective functionalization
• Ideal building block for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed couplings
• Stored in amber glass bottles with PTFE-lined caps to ensure stability
• Comprehensive analytical data (NMR, MS, IR) available upon request

Properties

• CAS Number: 1435-48-9
• Complexity: 97.1
• IUPAC Name: 2,4-dichloro-1-fluoro-benzene
• InChI: InChI=1S/C6H3Cl2F/c7-4-1-2-6(9)5(8)3-4/h1-3H
• InChI Key: BDJZCCWUSOZUQG-UHFFFAOYSA-N
• Exact Mass: 163.9595836
• Molecular Formula: C6H3Cl2F
• Molecular Weight: 164.99
• SMILES: C1=CC(=C(C=C1Cl)Cl)F
• Monoisotopic Mass: 163.9595836
• Synonyms: 1,3-Dichloro-4-fluorobenzene, 2,4-Dichlorofluorobenzene, Benzene, 2,4-dichloro-1-fluoro-, DTXSID30162443, EC 406-160-1, DTXCID5084934, 406-160-1, 604-366-8, 1435-48-9, 2,4-Dichloro-1-fluorobenzene, 2,4-dichloro-1-fluoro-benzene, MFCD00000580, Benzene,2,4-dichloro-1-fluoro-, 1,3-dichloro4-fluorobenzene, SCHEMBL225710, SCHEMBL530773, SCHEMBL975699, SCHEMBL977662, CHEMBL2263223, BDJZCCWUSOZUQG-UHFFFAOYSA-, 2,4-Dichloro-1-fluorobenzene #, BCP24451, SBB087865, 2,4-Dichloro-1-fluorobenzene, 99%, AKOS005762927, CS-W010825, FS-4032, DB-019913, D2059, NS00006153, ST50405403, EN300-21377, 2,4-Dichlorofluorobenzene;1,3-Dichloro-4-fluorobenzene, InChI=1/C6H3Cl2F/c7-4-1-2-6(9)5(8)3-4/h1-3H

Application

2,4-Dichloro-1-fluorobenzene serves as a critical precursor in pharmaceutical synthesis, particularly for manufacturing active pharmaceutical ingredients (APIs) with dichlorophenyl motifs. Its differential halogen reactivity enables selective derivatization in agrochemical production, forming herbicides and fungicides. The compound is also employed in liquid crystal and polymer synthesis, where its rigid aromatic core and halogen substituents modify material properties.

Safety and Hazards

GHS Hazard Statements

• H226: Flammable liquid and vapor [Warning Flammable liquids]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (66.7%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• STOT RE 2 (66.7%)
• Aquatic Chronic 2 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.