Description

(3,4,5-Trifluorophenyl)boronic Acid (contains varying amounts of Anhydride) is a high-purity boronic acid derivative extensively used in organic synthesis and pharmaceutical research. With the molecular formula C₆H₄BF₃O₂ and CAS number 143418-49-9, this compound is a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds in complex molecule synthesis. The product may contain varying amounts of anhydride, which should be considered during experimental planning. It is supplied as a white to off-white crystalline powder with excellent stability under recommended storage conditions (2-8°C, dry, inert atmosphere). Ideal for researchers and scientists in medicinal chemistry, material science, and agrochemical development, this reagent is rigorously tested for purity and consistency to ensure reliable performance in demanding applications.

Properties

• CAS Number: 143418-49-9
• Complexity: 146
• IUPAC Name: (3,4,5-trifluorophenyl)boronic acid
• InChI: InChI=1S/C6H4BF3O2/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,11-12H
• InChI Key: UHDDEIOYXFXNNJ-UHFFFAOYSA-N
• Exact Mass: 176.0256440
• Molecular Formula: C6H4BF3O2
• Molecular Weight: 175.90
• SMILES: B(C1=CC(=C(C(=C1)F)F)F)(O)O
• Topological: 40.5
• Monoisotopic Mass: 176.0256440
• Synonyms: (3,4,5-trifluorophenyl)boronic Acid, (3,4,5-Trifluorophenyl)boronic Acid (contains varying amounts of Anhydride), 604-355-8, 3,4,5-Trifluorophenylboronic acid, 143418-49-9, 3,4,5-Trifluorobenzeneboronic Acid, 3,4,5-Trifluorophenyl boronic acid, MFCD02093069, Boronic acid, (3,4,5-trifluorophenyl)-, BORONIC ACID, B-(3,4,5-TRIFLUOROPHENYL)-, EC 604-355-8, AKOS BRN-0138, SCHEMBL177479, DTXSID60370438, 3,4,5-Trifluorphenylboronic acid, BCP22735, CS-D1006, (3,4,5-trifluorophenyl)boronicAcid, 3,4,5-trifluoro-phenylboronic acid, 3,4,5-trifluorobenzene boronic acid, SBB089100, AKOS004116551, AB10760, AC-5392, BCP9000265, FT70125, GS-6729, (3,4,5-trifluoro-phenyl)-boronic acid, NCGC00249510-01, HY-32892, SY007885, 3,4,5-TRIFLUOROPHENYLBORONIC AICD, DB-028244, NS00005502, T2300, EN300-53326, 3 pound not4 pound not5-Trifluorophenyl boronic acid, Z798912500, 3,4,5-Trifluorophenylboronic acid pound contains varying amounts of Anhydride pound(c)

(3,4,5-Trifluorophenyl)boronic Acid is widely employed in Suzuki-Miyaura cross-coupling reactions to synthesize biaryl compounds for pharmaceutical intermediates. It serves as a key precursor in the development of fluorinated organic materials with enhanced electronic properties. Researchers also utilize it in PET tracer synthesis and as a ligand in catalytic systems. Its trifluorophenyl moiety is valuable for modulating lipophilicity and metabolic stability in drug candidates.

Safety and Hazards

GHS Hazard Statements

• H302 (93.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H318 (89.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H411 (90.5%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P264, P264+P265, P270, P273, P280, P301+P317, P305+P354+P338, P317, P330, P391, and P501

Hazard Classes and Categories

• Acute Tox. 4 (93.1%)
• Eye Dam. 1 (89.7%)
• Aquatic Chronic 2 (90.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.