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Atomfair 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol NLG919, GDC-0919, Navoximod C18H22N2O CAS 1402836-58-1

1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol (CAS: 1402836-58-1), also known as NLG919 or GDC-0919 , is a high-purity small molecule inhibitor with the molecular formula C18H22N2O . This compound is widely recognized in immunological and oncology research for its role as a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor , which modulates tryptophan metabolism and immune responses. With a molecular weight of 282.38 g/mol , it is supplied as a lyophilized powder or in solution, ensuring optimal stability and performance in experimental settings. Ideal for researchers studying cancer immunotherapy, autoimmune diseases, and inflammatory pathways, this product meets rigorous quality standards for reproducibility and reliability in preclinical…

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Description

1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol (CAS: 1402836-58-1), also known as NLG919 or GDC-0919, is a high-purity small molecule inhibitor with the molecular formula C18H22N2O. This compound is widely recognized in immunological and oncology research for its role as a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, which modulates tryptophan metabolism and immune responses. With a molecular weight of 282.38 g/mol, it is supplied as a lyophilized powder or in solution, ensuring optimal stability and performance in experimental settings. Ideal for researchers studying cancer immunotherapy, autoimmune diseases, and inflammatory pathways, this product meets rigorous quality standards for reproducibility and reliability in preclinical studies. Store under recommended conditions to maintain integrity.

Properties

  • CAS Number: 1402836-58-1
  • Complexity: 355
  • IUPAC Name: 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
  • InChI: InChI=1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2
  • InChI Key: YTRRAUACYORZLX-UHFFFAOYSA-N
  • Exact Mass: 282.173213330
  • Molecular Formula: C18H22N2O
  • Molecular Weight: 282.4
  • SMILES: C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O
  • Topological: 38.1
  • Monoisotopic Mass: 282.173213330
  • Synonyms: NLG919, 1402836-58-1, 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol, MFCD26142661, NLG919 (GDC-0919), 5H-Imidazo[5,1-a]isoindole-5-ethanol, alpha-cyclohexyl-, 1-Cyclohexyl-2-(5H-imidazo-[5,1-a]isoindol-5-yl)ethanol, CHEMBL3629569, YTRRAUACYORZLX-UHFFFAOYSA-N, GTPL9019, SCHEMBL13280897, DTXSID20735206, EX-A574, HMS3653M05, BCP09887, NLG919(GDC-0919,Navoximod), BDBM50126144, s7111, AKOS025287054, NLG919(GDC-0919)?, CCG-267268, CS-3512, SB16495, NCGC00386274-04, AC-30124, AS-35112, DA-45347, HY-13983, SY046802, SW219857-1, BRD-A62133859-001-01-1, BRD-A62133859-001-02-9, BRD-A62133859-001-03-7, Q27087945, 5H-Imidazo[5,1-a]isoindole-5-ethanol, |A-cyclohexyl-, 1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethan-1-ol, 1-cyclohexyl-2-[5H-imidazo[4,3-a]isoindol-5-yl]ethan-1-ol, 5-(2-Cyclohexyl-2-hydroxyethyl)-5H-imidazo[5,1-a]isoindole, a-Cyclohexyl-5H-imidazo[5,1-a]isoindole-5-ethanol; 1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol; NLG919

1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol (NLG919) is primarily used in research to investigate the inhibition of IDO1, an enzyme implicated in immune tolerance and tumor evasion. It serves as a key tool compound in studying tumor microenvironment modulation and T-cell suppression mechanisms. Applications include in vitro and in vivo models of cancer immunotherapy and inflammatory disorders. Its high selectivity makes it valuable for validating IDO1-targeted therapeutic strategies.

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

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Certain molecules may be protected by active patents or regulatory restrictions.

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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