Description

2-Chloro-5-methoxypyridine (CAS No. 139585-48-1) is a high-purity heterocyclic organic compound with the molecular formula C₆H₆ClNO. This versatile chemical intermediate features a chloro-substituted pyridine ring with a methoxy group at the 5-position, making it a valuable building block for pharmaceutical synthesis, agrochemical development, and materials science research. Our product is rigorously tested to ensure >98% purity (HPLC) and is supplied as a clear to pale yellow liquid or crystalline solid with excellent batch-to-batch consistency. Suitable for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a precursor for more complex nitrogen-containing heterocycles. Packaged under inert gas in amber glass vials or sealed drums to ensure stability and longevity.

Properties

• CAS Number: 139585-48-1
• Complexity: 89.1
• IUPAC Name: 2-chloro-5-methoxy-pyridine
• InChI: InChI=1S/C6H6ClNO/c1-9-5-2-3-6(7)8-4-5/h2-4H,1H3
• InChI Key: ZXGHKJHRHVDMSW-UHFFFAOYSA-N
• Exact Mass: 143.0137915
• Molecular Formula: C6H6ClNO
• Molecular Weight: 143.57
• SMILES: COC1=CN=C(C=C1)Cl
• Topological: 22.1
• Monoisotopic Mass: 143.0137915
• Synonyms: 2-CHLORO-5-METHOXYPYRIDINE, 139585-48-1, DTXSID90569474, DTXCID30520246, 846-748-9, Pyridine, 2-chloro-5-methoxy-, MFCD06659513, 2-chloro-5-methoxy-pyridine, SCHEMBL264991, SCHEMBL942143, SCHEMBL1145831, SCHEMBL6350390, SCHEMBL7969014, SCHEMBL28000611, ZXGHKJHRHVDMSW-UHFFFAOYSA-N, AKOS006239260, AB25956, AC-8282, CS-W005142, 2-Chloro-5-methoxypyridine, AldrichCPR, AS-14975, SY038294, DB-025230, EN300-53092

2-Chloro-5-methoxypyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and CNS-targeting drugs. The compound’s reactive chlorine and electron-rich pyridine ring make it ideal for Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. Researchers utilize this chemical in developing novel herbicides and fungicides due to its bioisosteric properties. In material science, it functions as a ligand precursor for catalytic systems and a monomer for conductive polymers.

Safety and Hazards

GHS Hazard Statements

• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2A (66.7%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.