Description

1-(6-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethanone (CAS No. 1383735-65-6) is a high-purity brominated pyrazolopyridine derivative with the molecular formula C₈H₆BrN₃O. This heterocyclic compound features a pyrazolo[4,3-b]pyridine core functionalized with a bromo substituent at the 6-position and an acetyl group at the 1-position, making it a valuable intermediate for pharmaceutical and agrochemical research. With a molecular weight of 240.06 g/mol, it is supplied as a crystalline solid with ≥95% purity (HPLC). Ideal for cross-coupling reactions, scaffold diversification, and medicinal chemistry applications, this compound is rigorously tested for quality, stability, and batch-to-batch consistency. Store under inert conditions at 2-8°C to maintain optimal stability.

Properties

• CAS Number: 1383735-65-6
• Complexity: 223
• IUPAC Name: 1-(6-bromopyrazolo[4,3-b]pyridin-1-yl)ethanone
• InChI: InChI=1S/C8H6BrN3O/c1-5(13)12-8-2-6(9)3-10-7(8)4-11-12/h2-4H,1H3
• InChI Key: DXLKIGFFFNFTHS-UHFFFAOYSA-N
• Exact Mass: 238.96942
• Molecular Formula: C8H6BrN3O
• Molecular Weight: 240.06
• SMILES: CC(=O)N1C2=C(C=N1)N=CC(=C2)Br
• Topological: 47.8
• Monoisotopic Mass: 238.96942
• Synonyms: 1383735-65-6, 1-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethanone, Ethanone, 1-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-, 1-(6-bromopyrazolo[4,3-b]pyridin-1-yl)ethanone, 1-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one, SCHEMBL14299256, DXLKIGFFFNFTHS-UHFFFAOYSA-N, MFCD23162252, AKOS027441330, DA-30801, WS-01592, CS-0311897, F18442, 1-(6-Bromo-pyrazolo[4,3-b]pyridin-1-yl)-ethanone

Application

This brominated pyrazolopyridine derivative serves as a key building block in the synthesis of biologically active molecules, particularly in kinase inhibitor development and CNS-targeting pharmaceuticals. Its reactive bromo group enables efficient Suzuki-Miyaura and Buchwald-Hartwig couplings for structural diversification. Researchers also utilize it as a precursor for fluorescent probes due to the conjugated heterocyclic core. Suitable for high-throughput screening libraries in drug discovery pipelines.

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