Description

3-Bromo-2,5-dichloropyridine (CAS No. 138006-41-4) is a high-purity halogenated pyridine derivative widely used in pharmaceutical, agrochemical, and material science research. This compound, with the molecular formula C₅H₂BrCl₂N, serves as a versatile building block for the synthesis of complex heterocyclic frameworks due to its reactive bromo and chloro substituents. It is supplied as a crystalline solid with >98% purity (HPLC), ensuring optimal performance in cross-coupling reactions, nucleophilic substitutions, and other transformative processes. Ideal for researchers requiring precise functionalization of pyridine scaffolds, this product is rigorously tested for consistency and stability under standard laboratory conditions. Packaged in amber glass vials under inert atmosphere to prevent degradation, it is suitable for high-throughput screening and advanced synthetic applications.

Properties

• CAS Number: 138006-41-4
• Complexity: 101
• IUPAC Name: 3-bromo-2,5-dichloro-pyridine
• InChI: InChI=1S/C5H2BrCl2N/c6-4-1-3(7)2-9-5(4)8/h1-2H
• InChI Key: CDBHWRZEXFQNBI-UHFFFAOYSA-N
• Exact Mass: 224.87477
• Molecular Formula: C5H2BrCl2N
• Molecular Weight: 226.88
• SMILES: C1=C(C=NC(=C1Br)Cl)Cl
• Topological: 12.9
• Monoisotopic Mass: 224.87477
• Synonyms: 3-Bromo-2,5-dichloropyridine, 138006-41-4, DTXSID20512574, DTXCID30463381, 678-681-4, 3-bromo-2,5-dichloro-pyridine, PYRIDINE, 3-BROMO-2,5-DICHLORO-, MFCD06659484, 2,5-dichloro-3-bromopyridine, 2,5Dichloro-3-BromoPyridine, SCHEMBL899507, 3-bromo-2, 5-dichloropyridine, 3-bromo-2.5-dichloro-pyridine, CDBHWRZEXFQNBI-UHFFFAOYSA-N, BCP22191, AC-895, SBB054252, AKOS015851186, 3-Bromo-2 pound not5-dichloropyridine, AB25941, CS-W003322, AS-14935, SY022285, DB-023734, B4832, EN300-175311

3-Bromo-2,5-dichloropyridine is primarily employed as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals. Its reactive halogen sites enable efficient Suzuki-Miyaura and Buchwald-Hartwig couplings for drug discovery. The compound also finds utility in crop protection agent development and ligand design for catalytic systems. Researchers value its role in constructing fused pyridine architectures for optoelectronic materials.

Safety and Hazards

GHS Hazard Statements

• H301 (14.3%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (71.4%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (71.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (14.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (85.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (71.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (85.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (14.3%)
• Acute Tox. 4 (71.4%)
• Acute Tox. 4 (71.4%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (14.3%)
• Eye Irrit. 2 (85.7%)
• Acute Tox. 4 (71.4%)
• STOT SE 3 (85.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.