Description

(S)-3-Fluoropyrrolidine hydrochloride (CAS: 136725-53-6) is a high-purity chiral building block widely used in pharmaceutical research and fine chemical synthesis. This compound, with the molecular formula C₄H₉ClFN, features a stereospecific (S)-configuration at the 3-position of the pyrrolidine ring, making it invaluable for enantioselective synthesis. Its hydrochloride salt form ensures excellent stability and solubility, facilitating its use in diverse reaction conditions. Rigorous quality control guarantees ≥97% purity, as confirmed by HPLC, NMR, and mass spectrometry. Ideal for medicinal chemistry, this reagent is supplied as a white to off-white crystalline powder, packaged under inert conditions to maintain integrity. Store at 2-8°C in a tightly sealed container to prevent moisture absorption.

Properties

• CAS Number: 136725-53-6
• Complexity: 46.8
• IUPAC Name: (3S)-3-fluoropyrrolidine;hydrochloride
• InChI: InChI=1S/C4H8FN.ClH/c5-4-1-2-6-3-4;/h4,6H,1-3H2;1H/t4-;/m0./s1
• InChI Key: LENYOXXELREKGZ-WCCKRBBISA-N
• Exact Mass: 125.0407551
• Molecular Formula: C4H9ClFN
• Molecular Weight: 125.57
• SMILES: C1CNC[C@H]1F.Cl
• Topological: 12
• Monoisotopic Mass: 125.0407551
• Synonyms: 136725-53-6, (s)-3-fluoropyrrolidine hydrochloride, (S)-(+)-3-Fluoropyrrolidine hydrochloride, (3S)-3-fluoropyrrolidine hydrochloride, (S)-3-FLUOROPYRROLIDINE HCL, Pyrrolidine, 3-fluoro-, hydrochloride (1:1), (3S)-, (3S)-3-fluoropyrrolidine;hydrochloride, MFCD04038718, C4H9ClFN, (S)-3-Fluoropyrrolidine (hydrochloride), (S)-(+)-3-FLUOROPYRROLIDINE, HCL, (S)-3-FLUORO-PYRROLIDINE HYDROCHLORIDE, Pyrrolidine, 3-fluoro-, hydrochloride, (S)-, SCHEMBL717319, DTXSID50584527, (3S)-3-fluoropyrrolidine, chloride, (S)-(+)-3-Fluoropyrrolidine HCl, (s)-3-fluoropyrrolidinehydrochloride, (S)-3-fluoropyrrolidin hydrochloride, SBB085616, (3S)-3-fluoropyrrolidin hydrochloride, (5)-3-fluoropyrrolidine hydrochloride, AKOS005255415, (S)-3-fluoropyrrolidin-1-ium chloride, CS-W004695, FF50598, HY-W004695, PS-9190, (S)(+)3-fluoropyrrolidine hydrochloride, (S)-3-floropyrrolidine hydrogen chloride, s-(+)-3-fluoropyrrolidine hydrochloride, (5)-(+)-3-fluoropyrrolidine hydrochloride, (S)-(-)-3-fluoropyrrolidine hydrochloride, (S)-(+)-3-fluoropyrrolidine hydrochloric acid, EN300-243764, S-(+)-3-Fluoropyrrolidine hydrochloride 98% ee, (S)-(+)-3-Fluoropyrrolidine hydrochloride, 97%, (3S)-3-Fluoropyrrolidine–hydrogen chloride (1/1)

(S)-3-Fluoropyrrolidine hydrochloride serves as a key intermediate in the synthesis of bioactive molecules, particularly in the development of fluorinated pharmaceuticals and agrochemicals. Its chiral structure is critical for constructing peptidomimetics and protease inhibitors. Researchers leverage its reactivity in nucleophilic substitutions and ring-opening reactions to introduce fluorinated motifs. This compound is also employed in asymmetric catalysis and as a ligand in metal-complexed reactions.

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