Description

4-Fluoro-3-methylbenzaldehyde (CAS No. 135427-08-6) is a high-purity aromatic aldehyde widely utilized in organic synthesis, pharmaceutical research, and material science. With the molecular formula C₈H₇FO, this compound features a fluoro-substituted methylbenzaldehyde structure, offering unique reactivity for electrophilic aromatic substitution and nucleophilic addition reactions. It is available as a clear to pale-yellow liquid or crystalline solid (depending on storage conditions) with a characteristic aromatic odor. This reagent is rigorously tested for quality, ensuring ≥97% purity (GC) for reliable performance in synthetic applications. Suitable for use under inert atmospheres, it is packaged in amber glass bottles to prevent degradation. Ideal for researchers developing fluorinated intermediates, liquid crystals, or bioactive molecules.

Properties

• CAS Number: 135427-08-6
• Complexity: 124
• IUPAC Name: 4-fluoro-3-methyl-benzaldehyde
• InChI: InChI=1S/C8H7FO/c1-6-4-7(5-10)2-3-8(6)9/h2-5H,1H3
• InChI Key: NRFKZFFVTGGEQF-UHFFFAOYSA-N
• Exact Mass: 138.048093005
• Molecular Formula: C8H7FO
• Molecular Weight: 138.14
• SMILES: CC1=C(C=CC(=C1)C=O)F
• Topological: 17.1
• Monoisotopic Mass: 138.048093005
• Synonyms: 4-Fluoro-3-methylbenzaldehyde, 135427-08-6, DTXSID90370547, DTXCID20321582, 670-735-5, 3-METHYL-4-FLUOROBENZALDEHYDE, MFCD01631431, 4-Fluoro-3-Methyl benzaldehyde, Benzaldehyde, 4-fluoro-3-methyl-, 4-fluoro-3-methyl-benzaldehyde, 4-FLUORO-M-TOLUALDEHYDE, SCHEMBL336067, 3-methyl-4-fluoro benzaldehyde, SCHEMBL3279463, NRFKZFFVTGGEQF-UHFFFAOYSA-N, BBL103749, SBB063863, STL557559, 4-Fluoro-3-methylbenzaldehyde, 97%, AKOS005254609, AC-3847, CS-W007668, PS-9082, SY017835, DB-023731, F0791, ST51021123, EN300-61152, doi:10.14272/NRFKZFFVTGGEQF-UHFFFAOYSA-N.1, F0001-0459, Z732814060, InChI=1/C8H7FO/c1-6-4-7(5-10)2-3-8(6)9/h2-5H,1H

4-Fluoro-3-methylbenzaldehyde serves as a key building block in the synthesis of fluorinated pharmaceuticals, agrochemicals, and specialty materials. It is commonly employed in Grignard reactions, reductive aminations, and as a precursor for heterocyclic compounds. Researchers value its role in modulating electronic properties of molecules due to the fluorine substituent. Suitable for Pd-catalyzed cross-coupling reactions and Schiff base formation.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (85.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (85.7%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.